Evidence map›Paper›PMID 41126223›Full record

ReviewItalian journal of pediatrics2025

Thermal water inhalation for allergic rhinitis and recurrent respiratory infections: a narrative review of the evidence.

Attilio Varricchio, Giulia Brindisi, Francesco Paolo Brunese, Maria Daglia, Giulio Dinardo, Lorenzo Drago, Alessandra Gori, Cristiana Indolfi, Matteo Naso, Enrico Tondina and 6 more

Abstract readReviewLetter
In one paragraph

Review in Italian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Attilio VarricchioDepartment of Otolaryngology, University of Molise, Campobasso, 86100, Italy.
Giulia BrindisiDepartment of Mother-Child, Urological Science, Sapienza University of Rome, Rome, Italy.
Francesco Paolo BrunesePrimary Care Paediatrics, ASL Caserta, Caserta, Italy.
Maria DagliaDepartment of Pharmacy, University of Napoli Federico II, Naples, Italy.
Giulio DinardoDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Lorenzo DragoLaboratory of Clinical Microbiology & Microbiome, Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
Alessandra GoriDepartment of Mother-Child, Urological Science, Sapienza University of Rome, Rome, Italy.
Cristiana IndolfiDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Matteo NasoAllergy Center, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Enrico TondinaPediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Chiara TrinciantiAllergy Center, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Antonio VarricchioUniversità Vita-Salute San Raffaele, Milan, Italy.
Anna Maria ZicariDepartment of Mother-Child, Urological Science, Sapienza University of Rome, Rome, Italy.
Michele Miraglia Del GiudiceDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Giorgio CiprandiAllergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy. gio.cip@libero.it.ORCID http://orcid.org/0000-0001-7016-8421
Nutraceutical and Medical Device Task Force of the Italian Society of Pediatric Allergy, Immunology (SIAIP)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allergic rhinitis (AR) and recurrent respiratory infections (RRIs) are common conditions that significantly impact quality of life and healthcare systems. Thermal water inhalation therapies have emerged as a potential non-pharmacological option due to their immunomodulatory and anti-inflammatory properties. This narrative review aimed to evaluate the efficacy and safety of thermal water inhalations in managing patients with AR and RRIs. The inclusion criteria were pertinent articles written in English and published in journals listed in PubMed. Six studies conducted in Italy, involving 548 participants (most of whom were children and adolescents), met the inclusion criteria. Significant improvements were observed in nasal mucociliary transport time, with reductions ranging from 2 to 8 min across treatment groups. Total Symptom Scores decreased significantly (one study reported a > 50% reduction). The frequency and duration of upper respiratory tract infections were reduced considerably in the treatment groups compared to the controls. However, results for nasal cytology were inconsistent, and heterogeneity in study designs limited comparability. The reviewed studies highlighted the potential of thermal water therapies to enhance mucociliary clearance, alleviate symptoms, and reduce reliance on other pharmacological treatments. On the other hand, these studies have a regional limitation and this review was not systematic. In conclusion, this narrative review may suggest that thermal water inhalations could be a promising option for managing patients with AR and RRIs, providing an alternative therapy with significant clinical benefits. Nevertheless, further high-quality, standardized, and international studies are necessary to confirm these findings and facilitate meta-analyses. These treatments could play a valuable role in reducing the burden of respiratory and allergic conditions.

Indexed as

Respiratory Tract InfectionsRhinitis, AllergicWaterAdministration, InhalationAdolescentChildHumansMucociliary ClearanceQuality of LifeRecurrenceWaterAllergic rhinitisMucociliary clearanceRecurrent respiratory infectionsSymptomsThermal water

Identifiers

PMID41126223
PMCPMC12542181

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.