ArticleBMC complementary medicine and therapies2025
Enhanced in vitro wound healing of human dermal fibroblasts using nanohydroxyapatite synthesized from Elaeagnus Angustifolia and loaded with crocin.
Article in BMC complementary medicine and therapies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimIn this study, we investigated the potential of hydroxyapatite nanoparticles (HA-NP) synthesized from Elaeagnus Angustifolia (HAEA-NP) and loaded with crocin (HAEA-NP@CR) to enhance the in vitro wound healing of human dermal fibroblasts (hDF).
methodHAEA-NPs were synthesized using the sol-gel technique and impregnated with crocin (CR) to create the HAEA-NP@CR formulation. The examination of CR loading and release was performed. The assessment of viability of hDFs following exposure to nanoparticles (NPs), CR, and HAEA-NP@CR was assessed. A scratch assay was performed to assess the rate of wound closure. Real-time PCR analysis was utilized to measure the expression levels of genes associated with wound healing.
resultAccording to our findings, CR had a loading capacity of 46.76%. It was released in a controlled manner from HAEA-NPs. The combination of HAEA-NP and CR significantly promoted the viability of hDFs and accelerated wound closure in an in vitro wound healing model. Furthermore, we observed an upregulation of key wound healing-related genes underlying the enhanced wound healing effect.
conclusionThese findings suggest that the use of HAEA-NP@CR holds promise as a novel approach to promote wound healing and may have potential applications in developing wound healing therapies.
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