Evidence map›Paper›PMID 41126095›Full record

ArticleBMC infectious diseases2025

Nocardia Nova bacteremia and viral pneumonia in a breast cancer patient post modified radical mastectomy: a case report.

Peng-Peng Tian, Li-Sha Zhu, Wen Fan, Liang-Cai Xie, Xian-Mo Wang, Chang-Li Zhang, Tian Tian

Abstract readCase Reports
PubMed Full text at PMC Publisher
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Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Peng-Peng TianLaboratory Department, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China.
Li-Sha ZhuLaboratory Department, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China.
Wen FanLaboratory Department, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China.
Liang-Cai XieLaboratory Department, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China.
Xian-Mo WangLaboratory Department, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China.
Chang-Li ZhangPharmaceutical Department, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China. changli_z@126.com.
Tian TianOphthalmology Department, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China. dmtt-316@163.com.

Funding

Jingzhou science and technology plan projects, Hubei Province, China 2024HD74
6 · The paper itself

Abstract

backgroundNocardia nova (N. nova) is a Gram-positive aerobic actinomycete and a rare pathogen that can cause severe infections, particularly in immunocompromised patients. CASE PRESENTATION: We report here a rare case of N. nova bacteremia combined with viral pneumonia in a 54-year-old woman who underwent a modified radical mastectomy for breast cancer. Post-surgery, she developed high fever and lung inflammation. Initial empirical therapy with levofloxacin was administered for the pulmonary infection. Upon identification of N. nova through blood cultures and antibiotic susceptibility testing (AST), treatment was switched to trimethoprim-sulfamethoxazole (TMP-SMX) and imipenem/cilastatin, which led to initial improvement. However, the patient relapsed and required an additional six months of antibiotics to achieve full recovery.

conclusionsEstablishing a diagnosis of nocardiosis is a precondition for successful antibiotic therapy. Nocardia bacteremia is a rare event, but it can be confirmed through blood cultures. Our report underscores the pathogenic potential of Nocardia species in patients with underlying conditions, highlighting the critical importance of prompt diagnosis and targeted treatment, especially in postoperative cancer patients at risk for co-infections.

Indexed as

BacteremiaCoinfectionNocardia InfectionsPneumonia, ViralPostoperative ComplicationsAnti-Bacterial AgentsBreast NeoplasmsFemaleHumansMastectomy, Modified RadicalMiddle AgedNocardiaTomography, X-Ray ComputedAnti-Bacterial AgentsBacteremiaBreast cancerCase reportNocardia novaViral pneumonia

Identifiers

PMID41126095
PMCPMC12541933

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.