ArticleLangenbeck's archives of surgery2025
Stage-dependent survival in gastric cancer: a Danish nationwide cohort study.
Article in Langenbeck's archives of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Suicide risk and mortality among patients with cancers of the digestive system: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Prognostic impact of lymph node ratio after suboptimal lymphadenectomy in gastric cancer: a retrospective cohort study with interaction analysis.World journal of surgical oncology · 2026Article
- Longitudinal trajectories of nutritional markers in patients with de novo Stage IV gastric cancer: a descriptive analysis using one-year survival as a reference.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Characteristics, treatment, and outcome of recurrent gastro-oesophageal adeno-carcinoma after perioperative chemotherapy and radical resection.Acta oncologica (Stockholm, Sweden) · 2026Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastric cancer remains a major clinical challenge with poor prognosis. This study investigated survival outcomes based on treatment strategy, tumor stage, and histology in Danish gastric cancer patients.
methodsFrom January 2013 to December 2021, 2,156 gastric cancers were registered in the Danish Esophagogastric Cancer Group database, covering 99% of national cases. Data were analyzed for patients with intestinal and diffuse-type cancers. Survival was assessed using Kaplan-Meier curves and Cox regression, adjusting for tumor stage, treatment, and demographics.
resultsMedian survival was significantly higher with surgery ± perioperative chemotherapy (SCT) than with palliative treatment. For the intestinal-type cancers, SCT resulted in a median survival of 45.2 months (95% CI [35.4-55.1]) versus 5.1 months (95% CI [4.6-5.7]) with palliative treatment. Patients with diffuse type, treated with SCT had a median survival exceeding 128 months, compared with 6.3 months (95% CI [5.2-7.5]) with palliative treatment. Patients receiving epirubicin based CT had a lower risk of death (HR 0.74, p = 0.04) compared with upfront surgery, while FLOT (5-fluorouracil, leucovorin, oxaliplatin, and docetaxel) similarly reduced the risk of death (HR 0.69, p = 0.04). No significant difference was observed between the two CT regimens. Palliative CT and radiotherapy improved survival over best supportive care (p < 0.001). Advanced tumor stage was associated with worse survival, while the histological subtype had no impact on overall survival outcomes.
conclusionThis study emphasizes the survival benefit of multimodal treatment strategies, especially surgery combined with perioperative CT. Palliative interventions also improved outcomes in advanced disease.
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