Evidence map›Paper›PMID 41125947›Full record

ArticleCalcified tissue international2025

Regular Proton-Pump Inhibitor Intake is Associated with Deterioration of Peripheral Bone Mineral Density, Microarchitecture, and Strength in Older Patients as Assessed by High-Resolution Peripheral Quantitative Computed Tomography (HR-pQCT).

Ursula Heilmeier, Alexandra Siegenthaler, Ursina Meyer, Marie Boensch, Melanie Kistler-Fischbacher, Caroline de Godoi Rezende Costa Molino, Bert van Rietbergen, Wei Lang, René Rizzoli, Robert Theiler and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Calcified tissue international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ursula HeilmeierDepartment of Geriatrics and Aging Research, University of Zurich, Zurich, Switzerland. Ursula.Heilmeier@ucsf.edu.
Alexandra SiegenthalerCentre on Aging and Mobility, University of Zurich and City Hospital Zurich, Zurich, Switzerland.
Ursina MeyerCentre on Aging and Mobility, University of Zurich and City Hospital Zurich, Zurich, Switzerland.
Marie BoenschCentre on Aging and Mobility, University of Zurich and City Hospital Zurich, Zurich, Switzerland.
Melanie Kistler-FischbacherCentre on Aging and Mobility, University of Zurich and City Hospital Zurich, Zurich, Switzerland.
Caroline de Godoi Rezende Costa MolinoDepartment of Geriatrics, University of Basel, Basel, Switzerland.
Bert van RietbergenDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Wei LangCentre on Aging and Mobility, University of Zurich and City Hospital Zurich, Zurich, Switzerland.
René RizzoliDivision of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
Robert TheilerDepartment of Geriatrics and Aging Research, University of Zurich, Zurich, Switzerland.
Andreas EgliDepartment of Geriatrics, University of Basel, Basel, Switzerland.
Heike Annette Bischoff-FerrariDepartment of Geriatrics, University of Basel, Basel, Switzerland. HA.Bischoff-Ferrari@felixplatter.ch.

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung PP00B-114864Velux Stiftung 441
6 · The paper itself

Abstract

Proton-pump inhibitors (PPI) are widely used among older adults and PPI intake has been associated with increased fracture risk. However, their association with bone microarchitecture and strength remains unclear as prior clinical PPI studies were restricted to lower-resolution bone imaging techniques such as DXA. Using high-resolution peripheral computed tomography (HR-pQCT), we prospectively investigated whether long-term PPI use was associated with changes in volumetric bone mineral densities, bone microarchitecture, and strength in older patients. 189 patients aged ≥ 60 years (n = 24 persistent PPI users [p-PPI user], and n = 165 non-PPI users), enrolled as part of a 2-year vitamin D RCT, underwent HR-pQCT scanning of the tibia and radius at 0 and 2 years. Bone volumetric density (vBMD), microarchitectural and strength parameters were computed and adjusted linear regression models without and with adjustments, including age, sex, BMI, and treatment groups, were employed to compare changes between p-PPI users and non-PPI users. At baseline, both groups were comparable with respect to age, vBMDs, bone microarchitecture, and sex. During follow-up, p-PPI users lost significantly more distal tibial total volumetric BMD (ΔTt.BMD: - 8.58 vs. - 2.45 mg/cm

Indexed as

Bone and BonesBone DensityProton Pump InhibitorsAgedAged, 80 and overFemaleHumansMaleMiddle AgedProspective StudiesTibiaTomography, X-Ray ComputedProton Pump InhibitorsAdverse drug eventsBone biomechanicsBone microarchitectureChronic PPI useGeriatricsHigh-resolution peripheral quantitative computed tomographyRandomized control trialVitamin D

Identifiers

PMID41125947
PMCPMC12546302

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.