Evidence map›Paper›PMID 41125892›Full record

ArticleNature2025

Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion.

Giovanni Luchetti, Marin V Miner, Rachael M Peterson, William P Scott, Praveen Krishnamoorthy, Eric M Kofoed, Angel G Jimenez, Hua Zhang, Man Wah Tan, Rohit Reja and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Giovanni LuchettiDepartment of Discovery Oncology, Genentech, South San Francisco, CA, USA. luchettg@gene.com.
Marin V MinerDepartment of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0002-3215-1490
Rachael M PetersonDepartment of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.ORCID 0009-0001-0782-5107
William P ScottDepartment of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0002-1473-4377
Praveen KrishnamoorthyDepartment of Pathology, Genentech, South San Francisco, CA, USA.
Eric M KofoedDepartment of Immunology and Infectious Diseases, Genentech, South San Francisco, CA, USA.
Angel G JimenezDepartment of Immunology and Infectious Diseases, Genentech, South San Francisco, CA, USA.
Hua ZhangDepartment of Translational Immunology, Genentech, South San Francisco, CA, USA.
Man Wah TanDepartment of Immunology and Infectious Diseases, Genentech, South San Francisco, CA, USA.ORCID 0000-0002-7748-212X
Rohit RejaDepartment of Physiological Chemistry, Genentech, South San Francisco, CA, USA.
Tommy K CheungDepartment of Proteomic and Genomic Technologies, Genentech, South San Francisco, CA, USA.
Elizabeth SkippingtonDepartment of OMNI Bioinformatics, Genentech, South San Francisco, CA, USA.
Yuxin LiangDepartment of Proteomic and Genomic Technologies, Genentech, South San Francisco, CA, USA.
Christopher M RoseDepartment of Proteomic and Genomic Technologies, Genentech, South San Francisco, CA, USA.
Nobuhiko KayagakiDepartment of Physiological Chemistry, Genentech, South San Francisco, CA, USA.ORCID 0000-0001-8129-1740
Kim NewtonDepartment of Physiological Chemistry, Genentech, South San Francisco, CA, USA.ORCID 0000-0002-4197-0340
Isabella RauchDepartment of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA. rauchi@ohsu.edu.ORCID 0000-0003-1897-5693
Vishva M DixitDepartment of Physiological Chemistry, Genentech, South San Francisco, CA, USA. dixit@gene.com.ORCID 0000-0001-6983-0326

Funding

The role of the tuft cell inflammasome in infectionR01AI167974 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI Isabella Rauch · 2022 to 2026
$1.9M
Interdisciplinary Training in Microbial Pathogenesis and ImmunologyT32AI170496 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI Patrizia Caposio, Scott M Landfear · 2023 to 2026
$1.5M
The interplay between enterobacteria-mediated inhibition of intestinal epithelial cell extrusion and activation of multiple inflammasomes.F31AI188838 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI Marin Miner · 2025 to 2026
$100k
NIAID NIH HHS F31 AI188838NIAID NIH HHS R01 AI167974NIAID NIH HHS T32 AI170496
6 · The paper itself

Abstract

Diverse pathogen-encoded virulence factors disable apoptosis, pyroptosis or necroptosis, the host cell death programs that remove infected cells

Indexed as

Citrobacter rodentiumEnteropathogenic Escherichia coliEpithelial Cellsrho-Associated KinasesAnimalsColonEnterobacteriaceae InfectionsEscherichia coli ProteinsFemaleHost-Pathogen InteractionsHumansInflammasomesIntestinal MucosaMaleMiceMice, Inbred C57BLEscherichia coli ProteinsInflammasomesProteasome Endopeptidase Complexrho-Associated KinasesRock1 protein, mouseUbiquitin-Protein Ligases

Identifiers

PMID41125892
PMCPMC12675278

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.