Evidence map›Paper›PMID 41125889›Full record

ArticleNature2025

Transcriptional interferences ensure one olfactory receptor per ant neuron.

Bogdan Sieriebriennikov, Olena Kolumba, Aurore de Beaurepaire, Jennifer Wu, Valentina Fambri, Eva Bardol, Yuwei Zhong, Ildar Gainetdinov, Danny Reinberg, Hua Yan and 1 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bogdan SieriebriennikovDepartment of Biology, New York University, New York, NY, USA.
Olena KolumbaDepartment of Biology, New York University, New York, NY, USA.
Aurore de BeaurepaireDepartment of Biology, New York University, New York, NY, USA.
Jennifer WuDepartment of Biology, New York University, New York, NY, USA.
Valentina FambriDepartment of Biology, New York University, New York, NY, USA.ORCID 0009-0004-5329-8282
Eva BardolDepartment of Biology, New York University, New York, NY, USA.
Yuwei ZhongDepartment of Biology, New York University, New York, NY, USA.ORCID 0009-0000-2668-3506
Ildar GainetdinovDepartment of Biology, New York University, New York, NY, USA.ORCID 0000-0003-1719-043X
Danny ReinbergHoward Hughes Medical Institute, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA. dxr1274@miami.edu.ORCID 0000-0003-4288-2016
Hua YanDepartment of Biology, University of Florida, Gainesville, FL, USA. hua.yan@ufl.edu.ORCID 0000-0002-6516-3287
Claude DesplanDepartment of Biology, New York University, New York, NY, USA. cd38@nyu.edu.ORCID 0000-0002-6914-1413

Funding

Stochastic choices in the retina and optic lobesR01EY013010 · NEI · NEW YORK UNIVERSITY · PI DESPLAN, CLAUDE · 1999 to 2025
$9.1M
Aging and rejuvenation: An ant model to study the regulation of longevityR01AG058762 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Claude Desplan, DANNY REINBERG · 2018 to 2026
$6.2M
Neuroplasticity in chemosensory-mediated social behaviorsR01DC020203 · NIDCD · UNIVERSITY OF FLORIDA · PI Hua Yan · 2023 to 2026
$1.7M
Bridging stochastic and deterministic paradigm of olfactory receptor choice in antsK99DC021991 · NIDCD · NEW YORK UNIVERSITY · PI SIERIEBRIENNIKOV, BOGDAN · 2024 to 2024
$133k
NEI NIH HHS R01 EY013010NIA NIH HHS R01 AG058762NIDCD NIH HHS K99 DC021991NIDCD NIH HHS R01 DC020203
6 · The paper itself

Abstract

To ensure specificity, sensory neurons must select and express a single receptor from often vast gene families, adhering to the rule of 'one receptor per neuron'. For example, each olfactory sensory neuron in mammals expresses only one odorant receptor (Or) gene

Indexed as

AntsInsect ProteinsOlfactory Receptor NeuronsReceptors, OdorantAnimalsGene Expression RegulationPromoter Regions, GeneticRNA, MessengerRNA Polymerase IITranscription, GeneticInsect ProteinsReceptors, OdorantRNA, MessengerRNA Polymerase II

Identifiers

PMID41125889
PMCPMC12871396

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.