Evidence map›Paper›PMID 41125887›Full record

ArticleNature2025

Bottom-up design of Ca

Yulai Liu, Connor Weidle, Ljubica Mihaljević, Joseph L Watson, Zhe Li, Le Tracy Yu, Sagardip Majumder, Andrew J Borst, Kenneth D Carr, Ryan D Kibler and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Reverse-engineering amyloid strains with generative protein design.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Yulai LiuDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-8175-6269
Connor WeidleDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-9354-2276
Ljubica MihaljevićDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Joseph L WatsonDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Zhe LiDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Le Tracy YuDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Sagardip MajumderDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Andrew J BorstDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0003-4297-7824
Kenneth D CarrDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0009-0005-1929-3952
Ryan D KiblerDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-6984-9887
Tamer M Gamal El-DinDepartment of Pharmacology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-7406-7393
William A CatterallDepartment of Pharmacology, University of Washington, Seattle, WA, USA.ORCID 0000-0001-5509-3580
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.ORCID 0000-0001-7896-6217

Funding

Structural Basis for Antiarrhythmic Drug ActionR01HL112808 · NHLBI · UNIVERSITY OF WASHINGTON · PI ZHENG, NING · 2012 to 2025
$7.8M
Designed Vehicles for Blood Brain Barrier TraversalR01AG063845 · NIA · UNIVERSITY OF WASHINGTON · PI BAKER, DAVID · 2019 to 2023
$2.5M
NHLBI NIH HHS R01 HL112808NIA NIH HHS R01 AG063845
6 · The paper itself

Abstract

Native ion channels play key roles in biological systems, and engineered versions are widely used as chemogenetic tools and in sensing devices

Indexed as

CalciumCalcium ChannelsProtein EngineeringCryoelectron MicroscopyDiffusionMagnesiumModels, MolecularPatch-Clamp TechniquesSodiumStrontiumCalciumCalcium ChannelsMagnesiumSodiumStrontium

Identifiers

PMID41125887
PMCPMC13560876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.