Evidence map›Paper›PMID 41125800›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Bridging the gap between prescription and participation: a systematic review and meta-analysis of factors influencing adherence to prehabilitation in gastrointestinal cancer surgery.

Kristy-Lee Raso, Michael David, Alice Melton, Sim Yee Cindy Tan, Janette L Vardy

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Prehabilitation for cancer surgery: a systematic review of qualitative literature from experienced stakeholders.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kristy-Lee RasoSydney Medical School, University of Sydney, Sydney, NSW, Australia. kristylee.raso@health.nsw.gov.au.
Michael DavidThe Daffodil Centre, The University of Sydney, A Joint Venture With Cancer Council NSW, Sydney, NSW, Australia.
Alice MeltonDepartment of Nutrition and Dietetics, Concord Repatriation General Hospital, Sydney, NSW, Australia.
Sim Yee Cindy TanSydney Medical School, University of Sydney, Sydney, NSW, Australia.
Janette L VardySydney Medical School, University of Sydney, Sydney, NSW, Australia. janette.vardy@sydney.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAdherence plays a critical role in determining the effectiveness of prehabilitation; however, achieving and maintaining it remains challenging. This systematic review and meta-analysis examined adherence rates and factors influencing participation in prehabilitation for gastrointestinal cancer surgery.

methodsSix databases (Embase, Medline, Web of Science, CINAHL, PsycINFO, and Cochrane) were searched to September 2024 for studies reporting prehabilitation interventions (unimodal or multimodal) and adherence. Data extraction, risk of bias, and certainty assessment were undertaken. Pooled adherence rates were analysed using random-effects meta-analysis, with meta-regression exploring determinants. The protocol was registered with PROSPERO (CRD42022301626).

resultsForty studies were included: 22 multimodal and 18 unimodal. Data from 32 studies (n = 1619; mean age 69 ± 6.8 years) revealed a pooled mean adherence rate of 75% (95% CI 66-84%). Adherence was higher for exercise (82%) and nutrition (83%) interventions but substantially lower for psychological support (42%). Multimodal programmes showed reduced adherence (67%) compared to unimodal approaches (83%). Meta-regression identified intervention duration as the only significant predictor, with a 2.6% decrease per additional day (p = 0.0046). Common barriers to adherence included logistics, exercise intensity, time constraints, and tolerance to nutritional supplements. Study-level limitations included inconsistent definitions and measurements of adherence, reliance on self-reported measures, and low certainty of evidence.

conclusionsAdherence to prehabilitation in gastrointestinal cancer surgery is generally moderate to high but lower in multimodal programmes and declines as the duration of the intervention increases. Standardising adherence reporting and integrating behavioural strategies and digital tools could improve adherence, equity, and outcomes. PROTOCOL REGISTRATION: The protocol for this systematic review and meta-analysis was registered with the PROSPERO database (CRD42022301626): https://www.crd.york.ac.uk/PROSPERO/view/301626 .

Indexed as

Gastrointestinal NeoplasmsPatient CompliancePreoperative CareHumansPreoperative ExerciseAdherenceBarriersGastrointestinal cancerPrehabilitationSurgery

Identifiers

PMID41125800

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.