Evidence map›Paper›PMID 41125603›Full record

ArticleNPJ Regenerative medicine2025

Platelet derived growth factor-AB modulates post-infarct myocardium leading to extended improvement in cardiac function.

Tejas Deshmukh, Robert D Hume, Siqi Chen, Sindhu Igoor, Sheryl L Foster, Tony Barry, Juntang Lu, Vu Tran, Jim Pouliopoulos, Andrew Jabbour and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Regenerative medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Tejas DeshmukhCentre for Heart Research, Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW, Australia.
Robert D HumeWestmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia.
Siqi ChenCentre for Heart Research, Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW, Australia.
Sindhu IgoorCentre for Heart Research, Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW, Australia.
Sheryl L FosterWestmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia.
Tony BarryDepartment of Cardiology, Westmead Hospital, Westmead, NSW, Australia.
Juntang LuDepartment of Cardiology, Westmead Hospital, Westmead, NSW, Australia.
Vu TranDepartment of Cardiology, Westmead Hospital, Westmead, NSW, Australia.
Jim PouliopoulosInnovation Centre & Clinical Imaging Facility, Victor Chang Cardiac Research Institute, Sydney, NSW, Australia.
Andrew JabbourInnovation Centre & Clinical Imaging Facility, Victor Chang Cardiac Research Institute, Sydney, NSW, Australia.
Niv VigderDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Stuart J CordwellSchool of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.
Sergey TumanovHeart Research Institute, Newtown, NSW, Australia.
Christopher NguyenCardiovascular Innovation Research Centre, Heart, Vascular, & Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
Yasuhito KotakeWestmead Applied Research Centre, University of Sydney, Sydney, NSW, Australia.
Samual TurnbullWestmead Applied Research Centre, University of Sydney, Sydney, NSW, Australia.
Tim CampbellWestmead Applied Research Centre, University of Sydney, Sydney, NSW, Australia.
Faraz PathanDepartment of Cardiology, Nepean Hospital, Kingswood, NSW, Australia.
Saurabh KumarDepartment of Cardiology, Westmead Hospital, Westmead, NSW, Australia.
Eddy KizanaCentre for Heart Research, Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW, Australia.
James J H ChongCentre for Heart Research, Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW, Australia. james.chong@sydney.edu.au.

Funding

Serial evaluation of cardioprotective effects of exercise training in heart failure using cardiac diffusion tensor MRIR01HL151704 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NGUYEN, CHRISTOPHER T · 2020 to 2024
$3.4M
Microstructural Response of the Myocardium to Mechanical LoadR01HL159010 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MEKKAOUI, CHOUKRI, NGUYEN, CHRISTOPHER T · 2021 to 2024
$3.2M
Modeling, measurement and prediction of cardiac magneto-stimulation thresholdsR01EB033853 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Bastien Guerin, Christopher T Nguyen · 2023 to 2026
$2.4M
National Health and Medical Research Council Postgraduate Scholarship APP2002783National Heart Foundation of Australia Health Professional's Scholarship 104615NHLBI NIH HHS R01 HL151704NHLBI NIH HHS R01 HL159010NIBIB NIH HHS R01 EB033853
6 · The paper itself

Abstract

Myocardial infarction (MI) contributes to significant morbidity and mortality globally. Platelet derived growth factor-AB (PDGF-AB) is potentially a novel translational therapeutic for improving cardiac function post-MI, which we assess here using a 60 day porcine left anterior descending artery occlusion ischemia-reperfusion model. MI was induced in 10 female Landrace swine, with 5 controls, 5 receiving PDGF-AB treatment and 2 additional shams. PDGF-AB improved left ventricular ejection fraction 58 days after MI, without affecting overall infarct scar size, as shown using serial cardiac magnetic resonance imaging. Preserved infarct zone microvascular function and increased vessel maturity was also observed. Multi-omic analyses showed that PDGF-AB treatment altered the expression of proteins, metabolites, and lipids that are known to be involved in myocardial energetics and redox balance. Novel therapeutics such as PDGF-AB may lead to more sustained salvage of cardiac function by modulating the post-MI microvasculature, myocardium and extracellular matrix.

Identifiers

PMID41125603
PMCPMC12546596

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.