ArticleNature communications2025
Non-equilibrium demixing and dissolution of chiral coacervates via intrinsic catalysis.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Sequence-Defined Short Peptide-Derived Coacervate Vesicles for Targeted Therapeutics.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Programmable Multiphasic Condensates Formed via Evaporation-Induced Phase Separation of Minimal Peptide Model.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Diastereomeric Configuration Modulates Liquid-Liquid Phase Separation and Catalysis in Minimalist Dipeptide Coacervates.Angewandte Chemie (International ed. in English) · 2026Article
- Metal-dependent and metal-free mechanisms of peptide condensate catalysts.Nature communications · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Membraneless organelles seen in extant biology leverage biochemical energy sources to realize intracellular non-equilibrium microcompartments. Constructing their synthetic mimics from small molecules can contribute towards our understanding of active phase separation and their role in the chemical emergence of compartments. Herein, we develop a model of synthetic membraneless organelles as non-equilibrium droplet phase and are accessed via homotypic interactions between small activated molecule and short peptide. The constituent short peptide's residues mimic hydrolase-like activity via covalent catalysis which leads to vacuolization and subsequent generation of the dissolved equilibrium phase as a function of time. Despite the short tetrameric sequence, the peptide residues help in demixing (phase separation) as well as catalysis which is critical for achieving such non-equilibrium behaviour. Importantly, the low molecular weight active coacervates behave like chiral microenvironment, which further promotes kinetic resolution in chemical transformations, thus mirroring the dynamic and functional attributes associated with complex membraneless organelles.
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Registered trials
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