ArticleNature communications2025
Genome-wide association study of childhood B-cell acute lymphoblastic leukemia reveals novel African ancestry-specific susceptibility loci.
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Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1citing papers in PubMed
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Who cites it
1 citing paper in PubMed.
- Characterization of Genetic Etiologic Factors for Pediatric Acute Lymphoblastic Leukemia in Large Childhood Cancer Survivorship Cohorts.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
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Authors and funding
43 authors.
Cindy ImDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA. imcindy@umn.edu.ORCID http://orcid.org/0000-0003-0931-9432
Andrew R RaduskiDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Lauren J MillsDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Kashi Raj BhattaraiDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-4781-9067
Robert J MobleyDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-2728-8206
Kelly R BarnettDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.
Zhanni LuDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Kenneth LiaoDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Nathan AndersonDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0009-0002-7145-3800
Rebecca A JohnsonDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Erica LangerDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-4528-5922
Anthony J HootenDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Alix E SeifDivision of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-1799-2582
Kathrin M BerntDivision of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-0691-356X
Matthew TsangDivision of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Brandon A MamouDivision of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Luis Gil-de-GómezDepartment of Molecular Biology, University of Cantabria-IDIVAL, Santander, Cantabria, Spain.ORCID http://orcid.org/0000-0002-7864-3976
Julie A WolfsonInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA.
Danielle N FriedmanDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-4668-9176
Neerav ShuklaDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Laura J KlesseHarold C. Simmons Comprehensive Cancer Center and the Department of Pediatrics, University of Texas Southwestern Medical School, Dallas, TX, USA.ORCID http://orcid.org/0000-0003-1323-7720
Erin L MarcotteDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Lingyun JiDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Alice DangChildren's Oncology Group, Monrovia, CA, USA.
Minjie LuoDivision of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-5788-3962
Yiming ZhongDivision of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Jalen LangieCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Charleston W K ChiangCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-0668-7865
Adam de SmithCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-4880-7543
Joseph L WiemelsCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-4838-9951
Andrew DeWanDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-7679-8704
Xiaomei MaDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-9472-8032
Catherine MetayerSchool of Public Health, University of California, Berkeley, CA, USA.
Zhaoming WangDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0001-7556-3869
Heather H NelsonDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
Nathan PankratzDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-5958-693X
Tianzhong YangDivision of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Saonli BasuDivision of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Lucie M TurcotteDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0003-4106-6172
Jun J YangDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-0770-9659
Daniel SavicDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-6693-0265
Michael E ScheurerDepartment of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-8379-6088
Logan G SpectorDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA. spect012@umn.edu.ORCID http://orcid.org/0000-0003-2516-0222
Funding
NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6MX-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MCOG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8MCOG U24 Funding 2026-2027U24CA196173 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Mignon Lee-Cheun Loh, Nilsa Del Carmen Ramirez Milan · 2015 to 2026
$62.5MGenome-Wide Association Study of Childhood Leukemia by Hispanic StatusR01CA155461 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MA, XIAOMEI, WIEMELS, JOSEPH LEO · 2011 to 2014
$4.1MSex and racial/ethnic differences in B-ALL genomicsR01CA239701 · NCI · UNIVERSITY OF MINNESOTA · PI SCHEURER, MICHAEL E., SPECTOR, LOGAN G. · 2020 to 2024
$3.5MGenetic pleiotropy across pediatric cancers, and cancer-related outcomesR01CA283333 · NCI · UNIVERSITY OF MINNESOTA · PI Cindy Im · 2024 to 2026
$2.2MSupport For Infrastructure of Childhood Leukemia Environmental ResearchU24ES028524 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 2023 to 2025
$1.1MNCCDPHP CDC HHS U58 DP003862NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA155461NCI NIH HHS R01 CA239701NCI NIH HHS R01 CA283333NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899NCI NIH HHS U24 CA196173NIEHS NIH HHS U24 ES028524
Abstract
B-cell acute lymphoblastic leukemia (B-ALL) is the most common pediatric malignancy. Given racial/ethnic differences in incidence and outcomes, B-ALL genome-wide association studies among children of African ancestry are needed. Leveraging multi-institutional datasets with 840 African American children with B-ALL and 3360 controls, nine loci achieved genome-wide significance (P < 5 × 10
Indexed as
Black or African AmericanGenetic Predisposition to DiseasePrecursor B-Cell Lymphoblastic Leukemia-LymphomaAdolescentAllelesCase-Control StudiesChildChild, PreschoolCore Binding Factor Alpha 2 SubunitDNA-Binding ProteinsETS Translocation Variant 6 ProteinFemaleGenome-Wide Association StudyHumansIkaros Transcription FactorInfantARID5B protein, humanCore Binding Factor Alpha 2 SubunitDNA-Binding ProteinsETS Translocation Variant 6 ProteinIkaros Transcription FactorIKZF1 protein, humanOncogene Proteins, FusionTEL-AML1 fusion proteinTranscription Factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.