Evidence map›Paper›PMID 41125580›Full record

ArticleNature communications2025

The role of cytochrome bc

Clara Aguilar-Pérez, Anne J Lenaerts, Cristina Villellas, Jerome Guillemont, John Dallow, Hannah Painter, Nicole C Ammerman, Anis Hassan, Guillaume Golovkine, Laure Brock and 27 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Menaquinone depletion resensitises bedaquiline-resistant tuberculosis.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Clara Aguilar-PérezJanssen Global Public Health, LLC, Janssen Pharmaceutica NV, Turnhoutseweg 30, Beerse, 2340, Antwerpen, Belgium. CAguila2@its.jnj.com.ORCID http://orcid.org/0000-0001-7438-9141
Anne J LenaertsMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, 80521, USA.
Cristina VillellasJanssen Global Public Health, LLC, Janssen Pharmaceutica NV, Turnhoutseweg 30, Beerse, 2340, Antwerpen, Belgium.
Jerome GuillemontJanssen Infectious Diseases Discovery, Janssen-Cilag, Val de Reuil, France.
John DallowDepartment of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Hannah PainterDepartment of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Nicole C AmmermanCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Anis HassanDepartment of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Guillaume GolovkineTranslational Biology, Infection Diseases, Evotec, 195, Route D'Espagne, 31100, Toulouse, France.ORCID http://orcid.org/0000-0001-8388-5892
Laure BrockTranslational Biology, Infection Diseases, Evotec, 195, Route D'Espagne, 31100, Toulouse, France.
Sylvie SordelloTranslational Biology, Infection Diseases, Evotec, 195, Route D'Espagne, 31100, Toulouse, France.
Aurélie ChauffourSorbonne Université, INSERM, Centre d'Immunologie et des Maladies Infectieuses, U1135, Paris, France.ORCID http://orcid.org/0000-0002-8846-5069
Alexandra AubrySorbonne Université, INSERM, Centre d'Immunologie et des Maladies Infectieuses, U1135, APHP Sorbonne Université, Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, Paris, France.
Thi Cuc MaiSorbonne Université, INSERM, Centre d'Immunologie et des Maladies Infectieuses, U1135, Paris, France.
Sarah WongSorbonne Université, INSERM, Centre d'Immunologie et des Maladies Infectieuses, U1135, Paris, France.
Taane G ClarkDepartment of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.ORCID http://orcid.org/0000-0001-8985-9265
Kiyean NamQurient Co. Ltd. C-dong 801, 242, Pangyo-ro, Bundang-gu, Seongnam-si, Republic of South Korea.
Jeongjun KimQurient Co. Ltd. C-dong 801, 242, Pangyo-ro, Bundang-gu, Seongnam-si, Republic of South Korea.
Jinho ChoiQurient Co. Ltd. C-dong 801, 242, Pangyo-ro, Bundang-gu, Seongnam-si, Republic of South Korea.
Marjolein CrabbeJanssen Research & Development, LLC, Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Antwerpen, Belgium.
Jorge EsquiviasDiscovery Chemistry, Janssen-Cilag SA a Johnson & Johnson company, C. Río Jarama, 75A, 45007, Toledo, Spain.
Nacer LounisJanssen Global Public Health, LLC, Janssen Pharmaceutica NV, Turnhoutseweg 30, Beerse, 2340, Antwerpen, Belgium.
Bart StoopsJanssen Research & Development, LLC, Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Antwerpen, Belgium.
Katie AmssomsJanssen Research & Development, LLC, Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Antwerpen, Belgium.
Jose M Bartolome-NebredaDiscovery Chemistry, Janssen-Cilag SA a Johnson & Johnson company, C. Río Jarama, 75A, 45007, Toledo, Spain.
Veronica GruppoMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, 80521, USA.
Gregory T RobertsonMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, 80521, USA.ORCID http://orcid.org/0000-0001-7157-4034
Nicolas VezirisSorbonne Université, INSERM, Centre d'Immunologie et des Maladies Infectieuses, U1135, APHP Sorbonne Université, Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, Paris, France.
Anna M UptonEvotec US inc., 303B College Road East, Princeton, NJ, 08540, USA.
Eric L NuermbergerCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-1440-9889
Vivian CoxJohnson & Johnson Innovative Medicine, Titusville, NJ, USA.
Lluis BallellDiscovery Chemistry, Janssen-Cilag SA a Johnson & Johnson company, C. Río Jarama, 75A, 45007, Toledo, Spain.
Benny BaetenJanssen Global Public Health, LLC, Janssen Pharmaceutica NV, Turnhoutseweg 30, Beerse, 2340, Antwerpen, Belgium.
Anil KoulJanssen Global Public Health, LLC, Janssen Pharmaceutica NV, Turnhoutseweg 30, Beerse, 2340, Antwerpen, Belgium.ORCID http://orcid.org/0009-0009-5542-4568
Alexander S PymJanssen Global Public Health, LLC, Janssen Pharmaceutica, 50-100 Holmers Farm Way, High Wycombe, HP12 4DP, UK.
Richard J Wall *Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.ORCID http://orcid.org/0000-0003-3487-3187
Dirk A Lamprecht *Janssen Global Public Health, LLC, Janssen Pharmaceutica NV, Turnhoutseweg 30, Beerse, 2340, Antwerpen, Belgium. dirk.lamprecht@uct.ac.za.ORCID http://orcid.org/0000-0003-1066-9026

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis (TB) remains the foremost cause of death from infectious diseases globally, prompting ongoing efforts to improve treatment options. This includes developing compounds with novel modes of action and identifying optimal treatment regimens that allow for treatment shortening. One promising strategy involves targeting cytochrome bc

Indexed as

Antitubercular AgentsElectron Transport Complex IIIMycobacterium tuberculosisTuberculosisAnimalsDisease Models, AnimalDrug Therapy, CombinationFemaleHumansMiceMicrobial Sensitivity TestsTuberculosis, Multidrug-ResistantAntitubercular AgentsElectron Transport Complex III

Identifiers

PMID41125580
PMCPMC12546632

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.