Evidence map›Paper›PMID 41125369›Full record

ArticleInternal medicine (Tokyo, Japan)2026

Two-year Outcomes of Remission Induction Therapy with Mepolizumab for Eosinophilic Granulomatosis with Polyangiitis: A Case Series.

Satoshi Suzuki, Tomoya Otani, Takuya Nishi, Keigo Ikeda, Naoto Tamura, Shinji Morimoto

Abstract read
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Satoshi SuzukiDepartment of Internal Medicine and Rheumatology, Juntendo University Urayasu Hospital, Japan.
Tomoya OtaniDepartment of Internal Medicine and Rheumatology, Juntendo University Urayasu Hospital, Japan.
Takuya NishiDepartment of Internal Medicine and Rheumatology, Juntendo University Urayasu Hospital, Japan.
Keigo IkedaDepartment of Internal Medicine and Rheumatology, Juntendo University Urayasu Hospital, Japan.
Naoto TamuraDepartment of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Japan.
Shinji MorimotoDepartment of Internal Medicine and Rheumatology, Juntendo University Urayasu Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mepolizumab, which selectively suppresses Interleukin-5, has been proven to be effective in treating eosinophilic granulomatosis with polyangiitis. However, the medium- to long-term outcomes of mepolizumab initiation in the early remission induction phase remain unclear. We investigated the outcomes up to 104 weeks in 10 patients in whom mepolizumab was initiated early in remission (mean, 14 days after glucocorticoid initiation). We found that the disease activity was promptly suppressed at 4 weeks and remained controlled for up to 104 weeks without relapse or adverse events. Glucocorticoids were discontinued at 104 weeks in 50% of patients, and prednisolone ≤4 mg/day was achieved in 70% of patients.

Indexed as

Antibodies, Monoclonal, HumanizedChurg-Strauss SyndromeGranulomatosis with PolyangiitisAdultAgedFemaleGlucocorticoidsHumansMaleMiddle AgedPrednisoloneRemission InductionTime FactorsTreatment OutcomeAntibodies, Monoclonal, HumanizedGlucocorticoidsmepolizumabPrednisoloneeosinophilic granulomatosis with polyangiitisglucocorticoidsIL-5mepolizumabremission induction

Identifiers

PMID41125369
PMCPMC13265096

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.