Evidence map›Paper›PMID 41125293›Full record

ArticleBMJ open2025

Associations of NLR and SIRI with all-cause mortality among adults with nasal

Ju Zou, Yuanyuan Xiao, Biyue Tian, Siyao Chen, Anhua Wu, Chunhui Li

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Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Ju ZouDepartment of Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yuanyuan XiaoDepartment of Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan, China.
Biyue TianDepartment of Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan, China.
Siyao ChenDepartment of Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan, China.
Anhua WuDepartment of Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan, China 404068@csu.edu.cn xywuanhua@csu.edu.cn.
Chunhui LiDepartment of Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan, China 404068@csu.edu.cn xywuanhua@csu.edu.cn.ORCID http://orcid.org/0000-0003-2418-5882

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aims to explore the associations of the neutrophil-to-lymphocyte ratio (NLR) and the systemic inflammatory response index (SIRI) with all-cause mortality among adults with nasal colonisation of

designA cross-sectional study.

settingThe National Health and Nutrition Examination Survey (2001-2004).

participantsA total of 10 600 adults aged 18 years or older were included in this study, of whom 2805 were colonised with nasal PRIMARY AND SECONDARY OUTCOME MEASURES: All-cause mortality was considered as primary outcomes. Survey-weighted Cox proportional hazards models were applied to evaluate the associations of NLR and SIRI with all-cause mortality after adjustment for confounders. Predictive performance was assessed using time-dependent receiver operating characteristic (ROC) curves, and survival differences were illustrated by Kaplan-Meier (K-M) analysis. Restricted cubic spline (RCS) models further examined potential non-linear associations.

resultsDuring a median follow-up of 197 months, 595 deaths occurred. The fully adjusted Cox model showed that elevated NLR (1.87 (1.32, 2.65), p<0.001) and SIRI (1.88 (1.43, 2.48), p<0.001) were significantly associated with increased all-cause mortality risk. These associations were consistent across subgroup analyses by sex, age, education, race, family poverty income ratio, smoking, drinking, diabetes, cancer and long-term care. K-M curves showed significantly lower survival rates in high NLR and SIRI groups (p<0.0001). RCS analysis revealed non-linear relationships between NLR and SIRI, with all-cause mortality (p>0.05).

conclusionsElevated NLR and SIRI levels are positively associated with higher all-cause mortality risk among adult individuals with nasal

Indexed as

NeutrophilsStaphylococcal InfectionsStaphylococcus aureusAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedNutrition SurveysProportional Hazards ModelsUnited StatesBACTERIOLOGYClinical Decision-MakingInfection controlINFECTIOUS DISEASESMortalityPublic health

Identifiers

PMID41125293
PMCPMC12548622

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.