Evidence map›Paper›PMID 41125233›Full record

ArticleJournal of medicinal chemistry2025

Apoptosis, Oxidative Stress, and Cell Cycle Disruption: Antitumor Effects of a Novel Palladium(II) Complexes.

Olga Klaudia Szewczyk, Piotr Roszczenko, Nurbey Gulia, Jarosław Fornalski, Adrianna Gumienna, Krzysztof Bielawski, Sławomir Szafert, Robert Czarnomysy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Olga Klaudia SzewczykDepartment of Synthesis and Technology of Drugs, Medical University of Białystok, Kilinskiego 1, 15-089 Białystok, Poland.ORCID 0000-0002-3719-6583
Piotr RoszczenkoDepartment of Biotechnology, Medical University of Białystok, Kilinskiego 1, 15-089 Białystok, Poland.ORCID 0000-0001-9180-5901
Nurbey GuliaFaculty of Chemistry, University of Wrocław, 14 F. Joliot-Curie, 50-383 Wrocław, Poland.ORCID 0000-0001-6518-1197
Jarosław FornalskiFaculty of Chemistry, University of Wrocław, 14 F. Joliot-Curie, 50-383 Wrocław, Poland.
Adrianna GumiennaFaculty of Chemistry, University of Wrocław, 14 F. Joliot-Curie, 50-383 Wrocław, Poland.
Krzysztof BielawskiDepartment of Synthesis and Technology of Drugs, Medical University of Białystok, Kilinskiego 1, 15-089 Białystok, Poland.
Sławomir SzafertFaculty of Chemistry, University of Wrocław, 14 F. Joliot-Curie, 50-383 Wrocław, Poland.
Robert CzarnomysyDepartment of Synthesis and Technology of Drugs, Medical University of Białystok, Kilinskiego 1, 15-089 Białystok, Poland.ORCID 0000-0002-7148-6111

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of novel metal-based anticancer agents with higher selectivity and lower toxicity is a major goal in oncology. In this study, four newly synthesized palladium(II) complexes (

Indexed as

Antineoplastic AgentsApoptosisCell CycleCoordination ComplexesOxidative StressPalladiumBreast NeoplasmsCell Cycle CheckpointsCell Line, TumorDrug Screening Assays, AntitumorFemaleHumansMCF-7 CellsMembrane Potential, MitochondrialReactive Oxygen SpeciesStructure-Activity RelationshipAntineoplastic AgentsCoordination ComplexesPalladiumReactive Oxygen Species

Identifiers

PMID41125233
PMCPMC12621177

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.