ArticleEuropean journal of dentistry2026
Analysis of Soft Tissue Healing Over Socket Orifice Sealed with Platelet-Rich Fibrin Membrane.
Article in European journal of dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- The Evolution of Extended Platelet-Rich Fibrin Membranes for Socket Grafting: Part Two: A Randomized Clinical Trial Comparing These Membranes with Collagen Membranes.Dentistry journal · 2026Article
- Synergistic effects of platelet-rich fibrin and CTLA4Ig gene-transfected porcine skin on accelerating wound healing in a rat model of deep second-degree burns: a mechanistic study.Frontiers in immunology · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Socket sealing is a technique for alveolar ridge preservation following tooth extraction. Leukocyte and platelet-rich fibrin (L-PRF), an autologous platelet-derived material rich in growth factors, is used to support healing. However, its benefits for soft tissue healing compared with collagen sponge or spontaneous healing remain unclear. This study evaluated soft tissue healing outcomes, wound margin distance, inflammation, postoperative pain, and wound closure area, among sockets treated with L-PRF membrane, collagen sponge, or spontaneous healing. Materials and Methods: A randomized controlled clinical trial was conducted on 45 extraction sites at the Faculty of Dentistry, Mahidol University, Bangkok, Thailand. Sockets were randomly assigned to L-PRF sealing, collagen sponge sealing, or spontaneous healing. Primary outcomes included wound margin distance reduction percentage, soft tissue healing index, and postoperative pain. The secondary outcome was wound closure area reduction percentage between the L-PRF and collagen sponge groups. Measurements were recorded postoperatively and on days 7, 14, and 21. Pain scores were recorded daily for 1 week. Age, sex, tooth position, and arch were evaluated as covariates. Statistical Analysis: One-way ANOVA with least significant difference post-hoc test was used for primary outcomes, and an independent Results: Forty-five teeth were enrolled. Three teeth from the collagen sponge group were excluded due to infection and loss to follow-up; three additional teeth were recruited using the original allocation and randomization protocol. On day 7, L-PRF showed a significantly superior soft tissue healing index than collagen sponge ( Conclusion: L-PRF improved soft tissue healing and reduced postoperative pain within the first week, but showed no added benefit in wound closure compared with collagen sponge or spontaneous healing. L-PRF may support short-term symptom relief but not enhanced post-extraction soft tissue regeneration at the clinical relevance level.
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Registered trials
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