Evidence map›Paper›PMID 41124888›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2025

Attenuated theta-band activity and cross-frequency coupling in schizophrenia during affective response inhibition.

Jacob D Kraft, Takakuni Suzuki, Margo W Menkes, Carolyn M Andrews, Melvin G McInnis, Patricia J Deldin, Ivy F Tso

Abstract read
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In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jacob D KraftDepartment of Psychology, University of South Dakota, Vermillion, SD, USA. Electronic address: jake.kraft@usd.edu.
Takakuni SuzukiDepartment of Psychology, University of Tulsa, Tulsa, OK, USA.
Margo W MenkesDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA; Department of Psychology, University of Michigan, Ann Arbor, MI, USA.
Carolyn M AndrewsTRAILS, A Project of TIDES Center, Ann Arbor, MI, USA.
Melvin G McInnisDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Patricia J DeldinDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Ivy F TsoDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA; Department of Psychiatry & Behavioral Health, The Ohio State University, Columbus, OH, USA.

Funding

Disrupted eye gaze perception as a biobehavioral marker of social dysfunction: An RDoC investigationR01MH122491 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TSO, IVY FEI · 2020 to 2024
$2.9M
Progression of Social Cognitive Deficits in Mid- and Late-Life Schizophrenia Spectrum DisordersR01MH135117 · NIMH · OHIO STATE UNIVERSITY · PI Ivy Fei Tso · 2024 to 2026
$2.6M
NCATS NIH HHS L30 TR004967NIMH NIH HHS L30 MH127715NIMH NIH HHS R01 MH122491NIMH NIH HHS R01 MH135117
6 · The paper itself

Abstract

objectiveSchizophrenia (SZ) is marked by impaired cognitive control; however, the underlying neural mechanisms remain unclear. This study examined theta-band (4-7 Hz) neural oscillatory activity and cross-frequency coupling with gamma (30-50 Hz) in an affective cognitive control paradigm in SZ in comparison with healthy controls (HC) and those with bipolar disorder (BD).

methodsThirty-two participants with SZ, 67 with BD, and 48 HC completed an affective Go/No-Go Task with emotional face stimuli during electroencephalography recording. Time-frequency decomposition quantified theta-band power and intertrial phase consistency (ITPC) over midline fronto-central areas. Theta-gamma phase-amplitude coupling (PAC; Kullback-Leibler Modulation Index) was indexed within the midline frontal area and cross-regionally between midline frontal theta and bilateral parietal gamma.

resultsParticipants with SZ displayed decreased midline frontal theta power, ITPC, and local midline frontal theta-gamma PAC compared to HC, with BD falling in between SZ and HC groups across all these measures. Theta power, ITPC, and theta-gamma PAC were correlated with behavioral performance, particularly in the SZ group.

conclusionFindings show abnormalities across the amplitude, phase consistency, and cross-frequency coordination aspects of theta-related activity when individuals with SZ engage in affective cognitive control. SIGNIFICANCE: This study supports the assertion that SZ is associated with abnormal theta-related neural activity.

Indexed as

AffectInhibition, PsychologicalSchizophreniaTheta RhythmAdultBipolar DisorderElectroencephalographyFemaleGamma RhythmHumansMaleMiddle AgedYoung AdultAffective cognitive controlBipolar disorderNeural oscillationsPhase-amplitude couplingSchizophreniaTime-frequency analysis

Identifiers

PMID41124888
PMCPMC13227916

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.