Evidence map›Paper›PMID 41124590›Full record

ArticleFamily practice2025

Changes in benzodiazepine, z-drug, and other sedative prescribing in primary care in Ireland between 2014 and 2022.

Molly Mattsson, Ahmed Hassan Ali, Fiona Boland, Michelle Flood, Ciara Kirke, Emma Wallace, Derek Corrigan, Mary E Walsh, Tom Fahey, Frank Moriarty

Abstract read
In one paragraph

Article in Family practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Molly MattssonSchool of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, 111 St Stephen's Green, Dublin 2, D02 VN51, Ireland.ORCID 0000-0002-7208-3613
Ahmed Hassan AliSchool of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, 111 St Stephen's Green, Dublin 2, D02 VN51, Ireland.
Fiona BolandData Science Centre, RCSI University of Medicine and Health Sciences, 123 St Stephen's Green, Dublin 2, D02 YN77, Ireland.
Michelle FloodSchool of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, 111 St Stephen's Green, Dublin 2, D02 VN51, Ireland.
Ciara KirkeNational Medication Safety Programme, HSE National Quality and Patient Safety Directorate, Dr Steevens' Hospital, Steevens' Lane, Dublin 8, D08 W2A8, Ireland.
Emma WallaceDepartment of General Practice, Western Gateway Building, University College Cork, Cork, T12 XF62, Ireland.
Derek CorriganFutureNeuro, RCSI University of Medicine and Health Sciences, 123 St Stephen's Green, Dublin 2, D02 VN77, Ireland.
Mary E WalshSchool of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, 111 St Stephen's Green, Dublin 2, D02 VN51, Ireland.ORCID 0000-0001-8920-7419
Tom FaheyDepartment of General Practice, RCSI University of Medicine and Health Sciences, 123 St Stephen's Green, Dublin 2, D02 VN77, Ireland.
Frank MoriartySchool of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, 111 St Stephen's Green, Dublin 2, D02 VN51, Ireland.ORCID 0000-0001-9838-3625

Funding

Health Research Board in IrelandHRB Applying Research into Policy and Practice Award ARPP/2020/004HRB Emerging Clinician Scientist Award ECSA/2020/002Secondary Data Analysis Projects SDAP-2019-023
6 · The paper itself

Abstract

backgroundThe trends in sedative use have varied in recent years. Benzodiazepines and z-drugs are indicated for anxiety and/or sleep disorders but should be limited to short-term use. The aim of this study is to examine trends and patterns in sedative prescribing in Ireland between 2014 and 2022, as well as comparing trends between Ireland and England within the same period.

methodsMonthly data on medicines prescribed and dispensed in primary care on the means-tested General Medical Services (GMS) scheme in Ireland were used. Volumes of prescribed benzodiazepine and z-drug use and patterns of prescribing, including initiations, discontinuations, chronic use, and high-risk prescribing were summarized per year. Other sedating agents (sedating antihistamines, antidepressants, and antipsychotics) were also analysed. Volume of use outcomes were compared with NHS data from England for the same period.

resultsThe rate of benzodiazepine and z-drug dispensings per 1000 GMS population decreased by 5%, from 1531 in 2014 to 1474 in 2022. By comparison in England, there was a steeper decrease of 27% in the dispensing rate and the level of use was substantially lower, falling from 288 dispensings per 1000 population in 2014 to 210 in 2022. In Ireland, dispensing rates were highest amongst women and older age groups. High-risk dispensings of benzodiazepines and z-drugs decreased over the study period. DISCUSSION: Despite decreases in benzodiazepine and z-drug dispensings, rates remain high in Ireland and may suggest a need for enhanced availability of non-pharmacological interventions, and improved education and deprescribing support for healthcare professionals.

Indexed as

BenzodiazepinesDrug PrescriptionsHypnotics and SedativesPractice Patterns, Physicians'Primary Health CareAdultAgedAntipsychotic AgentsEnglandFemaleHumansIrelandMaleMiddle AgedAntipsychotic AgentsBenzodiazepinesHypnotics and Sedativespharmacology/drug reactionspopulation healthprescribingprimary carepublic health

Identifiers

PMID41124590
PMCPMC12541714

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.