Observational studyRevista da Associacao Medica Brasileira (1992)2025
Is high-density lipoprotein cholesterol a prognostic marker in epithelial ovarian cancer?
Observational study in Revista da Associacao Medica Brasileira (1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe aim of the study was to assess the prognostic potential of high-density lipoprotein cholesterol levels in predicting survival for patients with epithelial ovarian cancer.
methodsThis is a retrospective observational study. The cutoff value for high-density lipoprotein cholesterol was determined through receiver operating characteristic analysis, revealing a value of 45 mg/dL. Patients in Group I had high-density lipoprotein cholesterol values <45 mg/dL, while patients in Group II had high-density lipoprotein cholesterol values ≥45 mg/dL.
resultsA total of 219 patients participated in the study, including 78 (36%) in group I and 141 (64%) in group II. high-density lipoprotein cholesterol (HR 0.44, 95%CI 0.27-0.73, p=0.001), age ≥65 (HR 3.02, 95%CI 1.87-4.58, p<0.001), and stage (HR 3.68, 95%CI 1.07-12.67, p=0.038) were identified as independent prognostic factors for overall survival in the multivariate analysis. High-density lipoprotein cholesterol (HR 0.44, 95%CI 0.27-0.72, p=0.001) and N1b (HR 2.32, 95%CI 1.33-4.03, p=0.003) were independent prognostic factors for disease-free survival in the multivariate analysis.
conclusionsIn epithelial ovarian cancer, high-density lipoprotein cholesterol levels were prognostic for both overall survival and disease-free survival.
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