Evidence map›Paper›PMID 41124403›Full record

ArticleRevista da Sociedade Brasileira de Medicina Tropical2025

Analysis of vulnerabilities and negatives outcomes of tuberculosis treatment in the Municipality of São Paulo, 2019 and 2021.

Rodrigo Contrera do Rio, Maria Josefa Penón Rujula, Rita Barradas Barata

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Article in Revista da Sociedade Brasileira de Medicina Tropical, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Rodrigo Contrera do RioSanta Casa de São Paulo, Faculdade de Ciências Médicas, Departamento de Clínica Médica, São Paulo, SP, Brasil.ORCID http://orcid.org/0009-0003-9063-8779
Maria Josefa Penón RujulaSanta Casa de São Paulo, Faculdade de Ciências Médicas, Departamento de Saúde Coletiva, São Paulo, SP, Brasil.ORCID http://orcid.org/0000-0003-0712-5669
Rita Barradas BarataSanta Casa de São Paulo, Faculdade de Ciências Médicas, Departamento de Saúde Coletiva, São Paulo, SP, Brasil.ORCID http://orcid.org/0000-0002-7215-9788

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo study the unfavorable outcomes of tuberculosis treatment, presenting individual, social, and program vulnerabilities in homeless, HIV-infected individuals and individuals living in areas of high social vulnerability in the city of São Paulo.

methodsCases were reported, confirmed, and monitored using the tuberculosis control program in the city of São Paulo. Social vulnerability was assessed using the São Paulo Social Vulnerability Index (SVI). Individuals analyzed in the study with more than one vulnerability condition were allocated to more than one vulnerability group, and the outcomes were analyzed separately. The reference category included the remaining cases. The following outcomes were examined: death, treatment abandonment, tuberculosis recurrence, and drug resistance.

resultsA total of 14,221 cases reported in 2019 and 2021 were studied; 11,322 lived in areas of high social vulnerability, 2,753 were HIV-infected, and 1,388 were homeless (the total exceeded 14,221, given that there were individuals with more than one vulnerability). All groups had higher incidence, prevalence, and mortality rates, as well as a higher risk of unfavorable outcomes. The risks were highest for homeless individuals, followed by HIV-infected individuals and those living in areas of high social vulnerability.

conclusionsCompared to individuals without the analyzed vulnerabilities, we found that unfavorable tuberculosis treatment outcomes were associated with different types of vulnerabilities, reflecting individual, social, and program vulnerabilities. Although the individuals studied had access to treatment, several vulnerabilities impacted the likelihood of successful treatment and challenged the tuberculosis control.

Indexed as

Antitubercular AgentsIll-Housed PersonsSocial VulnerabilityTuberculosisAdolescentAdultBrazilFemaleHIV InfectionsHumansIncidenceMaleMiddle AgedPrevalenceRisk FactorsSocioeconomic FactorsAntitubercular Agents

Identifiers

PMID41124403
PMCPMC12551588

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