Evidence map›Paper›PMID 41124286›Full record

ArticleScience translational medicine2025

Leucine-rich α-2-glycoprotein 1 initiates the onset of diabetic retinopathy in mice.

Giulia De Rossi, Ao-Wang Qiu, Maxime Berg, Thomas Burgoyne, Andrea Martello, Marlene E Da Vitoria Lobo, Matteo Rizzi, Sophie Mueller, Jack Blackburn, Yuxuan Meng and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Giulia De RossiInstitute of Ophthalmology, University College London, EC1V 9EL London, UK.ORCID 0000-0001-6163-4590
Ao-Wang QiuInstitute of Ophthalmology, University College London, EC1V 9EL London, UK.
Maxime BergDepartment of Mechanical Engineering, University College London, WC1E 7JE London, UK.ORCID 0000-0003-1403-1978
Thomas BurgoyneInstitute of Ophthalmology, University College London, EC1V 9EL London, UK.ORCID 0000-0002-8428-720X
Andrea MartelloInstitute of Ophthalmology, University College London, EC1V 9EL London, UK.ORCID 0000-0003-1790-7090
Marlene E Da Vitoria LoboInstitute of Ophthalmology, University College London, EC1V 9EL London, UK.ORCID 0000-0001-5620-1010
Matteo RizziInstitute of Ophthalmology, University College London, EC1V 9EL London, UK.
Sophie MuellerInstitute of Ophthalmology, University College London, EC1V 9EL London, UK.
Jack BlackburnInstitute of Ophthalmology, University College London, EC1V 9EL London, UK.
Yuxuan MengInstitute of Ophthalmology, University College London, EC1V 9EL London, UK.
Simon Walker-SamuelDepartment of Mechanical Engineering, University College London, WC1E 7JE London, UK.ORCID 0000-0003-3530-9166
Rebecca ShipleyDepartment of Mechanical Engineering, University College London, WC1E 7JE London, UK.ORCID 0000-0002-2818-6228
Colin J ChuInstitute of Ophthalmology, University College London, EC1V 9EL London, UK.ORCID 0000-0003-2088-8310
Sobha SivaprasadInstitute of Ophthalmology, University College London, EC1V 9EL London, UK.ORCID 0000-0001-8952-0659
John GreenwoodInstitute of Ophthalmology, University College London, EC1V 9EL London, UK.ORCID 0000-0003-4496-2984
Stephen E MossInstitute of Ophthalmology, University College London, EC1V 9EL London, UK.ORCID 0000-0002-7304-8879

Funding

Diabetes UK 18/0005856Diabetes UK 23/0006514Medical Research Council MR/X020827/1Wellcome Trust 206413Wellcome Trust 214046Wellcome Trust 224586
6 · The paper itself

Abstract

Diabetic retinopathy (DR) is a common complication of diabetes mellitus and a leading cause of visual impairment and blindness in the working-age population. The early stage of the disease is characterized by retinal capillary dysfunction, but the mechanisms whereby hyperglycemia disturbs capillary homeostasis at this initiating stage are poorly understood, posing a barrier to the development of effective early treatments. We used two mouse models of type I diabetes that replicate early features of human retinal vascular pathology. In both the streptozotocin (STZ) model, where hypoinsulinemia is chemically induced, and in the Ins2Akita model, which develops it spontaneously because of a mutation in the insulin gene, we observed early induction of the secreted glycoprotein gene leucine-rich α-2-glycoprotein 1 (

Indexed as

Diabetic RetinopathyGlycoproteinsAnimalsDiabetes Mellitus, ExperimentalDisease Models, AnimalHumansMiceMice, Inbred C57BLPericytesRetinaRetinal VesselsSignal TransductionTransforming Growth Factor betaVascular Endothelial Growth Factor AGlycoproteinsLRG1 protein, mouseTransforming Growth Factor betaVascular Endothelial Growth Factor A

Identifiers

PMID41124286
PMCPMC7618449

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.