Evidence map›Paper›PMID 41124282›Full record

ArticleScience translational medicine2025

LRRC8A constitutively inhibits pain hypersensitivity in rodent models by restraining NMDA receptor activity at spinal cord synapses.

Meichun Deng, Shao-Rui Chen, Meng-Hua Zhou, Jixiang Zhang, Yuying Huang, Hong Chen, Fernando Benavides, Rajan Sah, Hui-Lin Pan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. HIV-1 gp120 Induces Nociceptive Hypersensitivity via α2δ-1-Bound NMDA Receptors at Primary Afferent→Excitatory Neuron Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Meichun DengCenter for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-3558-1314
Shao-Rui ChenCenter for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-0426-8202
Meng-Hua ZhouCenter for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Jixiang ZhangCenter for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-1641-8650
Yuying HuangCenter for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Hong ChenCenter for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Fernando BenavidesDepartment of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Rajan SahDepartment of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-1092-1244
Hui-Lin PanCenter for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0001-8444-3770

Funding

Molecular Determinants of Synaptic Plasticity in Chronic PainR01NS101880 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Shao-Rui Chen, Hui-Lin Pan · 2017 to 2026
$4.1M
Mechanisms of Epigenetic Plasticity in Neuropathic PainR01NS132398 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Shao-Rui Chen, Hui-Lin Pan · 2023 to 2026
$1.8M
Neuronal Plasticity and Signaling in Neuropathic PainR01NS073935 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PAN, HUI-LIN · 2011 to 2015
$1.8M
NINDS NIH HHS R01 NS073935NINDS NIH HHS R01 NS101880NINDS NIH HHS R01 NS132398
6 · The paper itself

Abstract

Amplification of nociceptive transmission due to aberrant

Indexed as

HyperalgesiaMembrane ProteinsReceptors, N-Methyl-D-AspartateSpinal CordSynapsesAnimalsDisease Models, AnimalGanglia, SpinalHumansMaleMiceMice, KnockoutNeuralgiaPosterior Horn CellsRatsRats, Sprague-DawleyMembrane ProteinsReceptors, N-Methyl-D-Aspartate

Identifiers

PMID41124282
PMCPMC13044580

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.