Evidence map›Paper›PMID 41124274›Full record

ArticleScience advances2025

Mechanical contribution of germ cell specification in

Chan Liu, Hui Shi, Yuting Han, Pan Wang, Kexin Li, Zhishuai Zhang, Jiazheng Liu, Yafeng Zheng, Linlin Li, Limei Lin and 7 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Chan LiuShaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection, School of Ecology and Environment, Northwestern Polytechnical University, Xi'an 710129, China.ORCID 0000-0001-6123-0529
Hui ShiShaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection, School of Ecology and Environment, Northwestern Polytechnical University, Xi'an 710129, China.ORCID 0009-0002-6459-3039
Yuting HanShaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection, School of Ecology and Environment, Northwestern Polytechnical University, Xi'an 710129, China.ORCID 0009-0003-5539-4721
Pan WangShaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection, School of Ecology and Environment, Northwestern Polytechnical University, Xi'an 710129, China.ORCID 0009-0009-5204-1633
Kexin LiKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China.ORCID 0009-0007-7511-0000
Zhishuai ZhangKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China.
Jiazheng LiuSchool of Future Technology, University of Chinese Academy of Sciences, Beijing 101408, China.ORCID 0000-0002-2001-1597
Yafeng ZhengState Key Laboratory of Protein and Plant Gene Research, Beijing 100871, China.ORCID 0000-0002-1132-3433
Linlin LiSchool of Future Technology, University of Chinese Academy of Sciences, Beijing 101408, China.
Limei LinSchool of Future Technology, University of Chinese Academy of Sciences, Beijing 101408, China.
Chen LiangShaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection, School of Ecology and Environment, Northwestern Polytechnical University, Xi'an 710129, China.
Binjun QinShaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection, School of Ecology and Environment, Northwestern Polytechnical University, Xi'an 710129, China.
Hua HanSchool of Future Technology, University of Chinese Academy of Sciences, Beijing 101408, China.ORCID 0000-0003-4713-4631
Shunong BaiState Key Laboratory of Protein and Plant Gene Research, Beijing 100871, China.ORCID 0000-0002-9521-4073
Xiao LiuKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China.ORCID 0000-0001-8574-3126
Wenqian ChenShaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection, School of Ecology and Environment, Northwestern Polytechnical University, Xi'an 710129, China.ORCID 0000-0002-6675-8987
Feng ZhaoShaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection, School of Ecology and Environment, Northwestern Polytechnical University, Xi'an 710129, China.ORCID 0000-0001-5180-2095

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A central question in developmental biology is how germ lines are established. We studied the specification of male germ cells (GCs) within the anther. Here, we focused on the potential role of mechanics, an aspect of anther development that has been very poorly characterized. Using a combination of live imaging and mechanical measurements, we showed that GCs emerge within a special micromechanical niche, where the inner tissues exert pressure on the outer cell layers, placing themselves under compression. Mechanical perturbations impair tissue expansion patterns and severely compromise GC specification. Further investigations revealed that the master genetic regulator SPOROCYTELESS/NOZZLE (SPL/NZZ) was central in establishing this micromechanical environment via cell wall softening. In turn, the mechanical cues stabilized the transcription of

Indexed as

ArabidopsisFlowersGerm CellsGerm Cells, PlantArabidopsis ProteinsBiomechanical PhenomenaCell WallGene Expression Regulation, PlantArabidopsis Proteins

Identifiers

PMID41124274
PMCPMC12542957

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.