Evidence map›Paper›PMID 41124266›Full record

ArticleScience advances2025

Vasa vasorum plexus formation in intracranial aneurysm associates with microcalcification and wall thickening.

Mukhayyirkhuja Abdurakhmonov, Yasutaka Tobe, Juan R Cebral, Alireza Asadbeygi, Mehdi Ramezanpour, Masoud Zamani, Simon C Watkins, Julie A Phillippi, Alexander K Yu, Sepideh Amin-Hanjani and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Analysis of the Role of Vasa Vasorum in the Oxygen Transport to the Aneurysm Wall.International journal for numerical methods in biomedical engineering · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mukhayyirkhuja AbdurakhmonovDepartment of Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0009-0009-1304-4233
Yasutaka TobeDepartment of Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0003-0473-0644
Juan R CebralDepartment of Bioengineering, George Mason University, Fairfax, VA 22030, USA.
Alireza AsadbeygiDepartment of Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0002-3734-8110
Mehdi RamezanpourDepartment of Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Masoud ZamaniDepartment of Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0009-0002-3717-8622
Simon C WatkinsDepartment of Cell Biology, University of Pittsburgh, PA 15261, USA.ORCID 0000-0003-4092-1552
Julie A PhillippiDivision of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh.ORCID 0000-0002-9879-2039
Alexander K YuNeuroscience and Orthopedic Institutes, Allegheny Health Network, Pittsburgh, PA 15212, USA.ORCID 0000-0002-1582-7938
Sepideh Amin-HanjaniDepartment of Neurological Surgery, University Hospital Cleveland Medical Center, Cleveland, OH 44106, USA.ORCID 0000-0002-1289-4596
Fady T CharbelDepartment of Neurosurgery, University of Illinois at Chicago, Chicago, IL 60612, USA.
Naoki KanekoDepartment of Interventional Neuroradiology, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-3579-7908
Boyle C ChengDepartment of Neurological Surgery, Allegheny Health Network, Pittsburgh, PA 15212, USA.ORCID 0000-0002-1725-5515
Amir R DehdashtiDepartment of Neurosurgery, Donald and Barbara Zucker School of Medicine at Hofstra Northwell, Manhasset, NY 11549, USA.ORCID 0000-0002-9320-3098
Timothy WhiteDepartment of Neurosurgery, Donald and Barbara Zucker School of Medicine at Hofstra Northwell, Manhasset, NY 11549, USA.ORCID 0000-0002-3604-4334
Anne M RobertsonDepartment of Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0002-5063-4293

Funding

Improving Cerebral Aneurysm Risk Assessment through Understanding Wall Vulnerability and Failure ModesR01NS097457 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CEBRAL, JUAN R, ROBERTSON, ANNE MARIE · 2016 to 2025
$6.0M
Bridging the Gap from Hemodynamic Stress to Intracranial Aneurysm Instability: An Integrated Multimodal ApproachR01NS121286 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KANEKO, NAOKI · 2021 to 2025
$2.5M
Request for a Nikon A1R Multiphoton MicroscopeS10OD025041 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WATKINS, SIMON C · 2018 to 2018
$870k
NIH HHS S10 OD025041NINDS NIH HHS R01 NS097457NINDS NIH HHS R01 NS121286
6 · The paper itself

Abstract

Intracranial aneurysms (IAs) affect about 3% of the population, often leading to catastrophic outcomes upon rupture. Vasa vasorum, microvessels supplying arterial walls, are conjectured to induce inflammation and leakage in IAs that drive adverse remodeling. Using scanning immunofluorescent multiphoton imaging and micro-computed tomography to visualize intact IA specimens, we identified an extensive vasa vasorum plexus in the IA wall. Our quantitative analyses show significant colocalization of vasa vasorum with calcifications, a strong correlation with increased wall thickness (

Indexed as

CalcinosisIntracranial AneurysmVasa VasorumAgedFemaleHumansMaleMiddle AgedX-Ray Microtomography

Identifiers

PMID41124266
PMCPMC12542963

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.