Evidence map›Paper›PMID 41124213›Full record

ArticleJournal of natural products2025

Discovery of Na

Adetola H Adewole, Bhuwan Khatri Chhetri, Ghada M Abdelwahab, Riya Bhanushali, Anne Marie Sweeney-Jones, Madison Greene, Jaehoon Shim, Carter K Asef, Patric Vaelli, Lee Barrett and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of natural products, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Adetola H AdewoleSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.ORCID 0000-0003-4983-245X
Bhuwan Khatri ChhetriSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Ghada M AbdelwahabSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.ORCID 0000-0001-5184-3882
Riya BhanushaliSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Anne Marie Sweeney-JonesSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Madison GreeneSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Jaehoon ShimF.M. Kirby Neurobiology Center, Boston Children's Hospital, and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, United States.
Carter K AsefSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.ORCID 0000-0002-5020-0583
Patric VaelliDepartment of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, United States.
Lee BarrettF.M. Kirby Neurobiology Center, Boston Children's Hospital, and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, United States.
Facundo M FernándezSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.ORCID 0000-0002-0302-2534
Cassandra L QuaveDepartment of Dermatology, Center for the Study of Human Health, Emory University, Atlanta, Georgia 30322, United States.
Julia KubanekSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.

Funding

Unravelling Mechanisms and Novel Therapeutic Targets for Peripheral Neuropathy and Neuropathic Pain (Diversity Supplement)R35NS105076 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI WOOLF, CLIFFORD J · 2018 to 2025
$9.5M
The USP Center for Drug Discovery and ConservationU19TW007401 · FIC · GEORGIA INSTITUTE OF TECHNOLOGY · PI HAY, MARK E · 2014 to 2018
$5.3M
Deep Ovarian Cancer MetabolomicsR01CA218664 · NCI · GEORGIA INSTITUTE OF TECHNOLOGY · PI Facundo Martin Fernandez, Jaeyeon Kim · 2018 to 2026
$4.3M
Development and validation of a high-throughput MicroED-driven platform technology for natural product discoveryR01AT011990 · NCCIH · EMORY UNIVERSITY · PI Hosea Martin Nelson, CASSANDRA LEAH QUAVE · 2022 to 2026
$3.2M
FIC NIH HHS U19 TW007401NCCIH NIH HHS R01 AT011990NCI NIH HHS R01 CA218664NINDS NIH HHS R35 NS105076
6 · The paper itself

Abstract

Automated high-throughput screening of a prefractionated extract library of marine macroorganisms identified 239 hits (hit rate 2.5%), including a marine algal extract that blocked the Na

Indexed as

Biological ProductsGlycolipidsNAV1.7 Voltage-Gated Sodium ChannelAnimalsAnthozoaDrug DiscoveryHigh-Throughput Screening AssaysHumansMarine BiologyMolecular StructurePoriferaRhodophytaBiological ProductsGlycolipidsNAV1.7 Voltage-Gated Sodium Channel

Identifiers

PMID41124213
PMCPMC12670511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.