ArticlePloS one2025
Type 2 diabetes remission and its predictors in an Indian cohort: A retrospective analysis of an intensive lifestyle intervention program.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Predictors of type 2 diabetes (T2D) remission following intensive lifestyle intervention (ILI) are poorly characterized, especially in high-risk populations, such as India. This study aimed to identify the key predictors of T2D remission after an ILI in an Indian population. This retrospective analysis included 2384 patients with T2D (age 30-75 years; body mass index (BMI) ≥23 kg/m² enrolled in an online one-year ILI program at the Freedom from Diabetes Clinic, India, between May 2021 and August 2023. The intervention included personalized plant-based diet, physical activity, stress management, and medical support. Remission was defined as maintaining glycated hemoglobin (HbA1c) < 48 mmol/mol (6.5%) for ≥3 months without glucose-lowering medications. Anthropometric and biochemical data were extracted from clinical records. Predictors were assessed using logistic regression analysis. Post- intervention, 744 patients (31.2%) achieved remission The remission group showed significantly greater improvements in weight (-8.5% vs. -5.2%), BMI (-8.6% vs. -5.2%), HbA1c (-15.3% vs. -12.4%), fasting insulin (-26.6% vs. -11.4%), and homeostatic model assessment of insulin resistance (HOMA-IR) (-37.3% vs. -19.7%), than the non-remission group (p <0.05). The predictors of remission included age (≤50 years), higher BMI (≥25 kg/m²), drug-naïve status, shorter disease duration (≤6 years), juice fasting, baseline HbA1c <7%, weight loss >10%, and post-intervention HOMA-IR <2.5 (p <0.05). Our findings demonstrate that a significant proportion of individuals with T2D can achieve remission through a comprehensive culturally adapted lifestyle program. The identification of both baseline and post-intervention predictors underscores the importance of early, personalized, and holistic care in diabetes management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.