Evidence map›Paper›PMID 41124105›Full record

ArticleJournal of chemical information and modeling2025

Dissecting the RAD51-BRC4 Interaction Landscape through Integrative Molecular Simulations and Experimental Biophysics.

Veronica Bresciani, Francesco Rinaldi, Pedro Franco, Stefania Girotto, Andrea Cavalli, Julian D Langer, Matteo Masetti, Mattia Bernetti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of chemical information and modeling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Veronica BrescianiComputational and Chemical Biology, Istituto Italiano di Tecnologia, Genova 16163, Italy.
Francesco RinaldiComputational and Chemical Biology, Istituto Italiano di Tecnologia, Genova 16163, Italy.ORCID 0000-0001-7042-2071
Pedro FrancoMax Planck Institute of Biophysics, Max-von-Laue-Strasse 3, Frankfurt am Main 60438, Germany.
Stefania GirottoStructural Biophysics Facility, Istituto Italiano di Tecnologia, Genoa 16163, Italy.ORCID 0000-0002-0339-6675
Andrea CavalliComputational and Chemical Biology, Istituto Italiano di Tecnologia, Genova 16163, Italy.
Julian D LangerMax Planck Institute of Biophysics, Max-von-Laue-Strasse 3, Frankfurt am Main 60438, Germany.ORCID 0000-0002-5190-577X
Matteo MasettiDepartment of Pharmacy and Biotechnology (FABIT), Alma Mater Studiorum─ Università di Bologna, Bologna 40126, Italy.ORCID 0000-0002-3757-7802
Mattia BernettiComputational and Chemical Biology, Istituto Italiano di Tecnologia, Genova 16163, Italy.ORCID 0000-0002-4373-9310

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The interaction between the RAD51 and BRCA2 proteins is central to homologous recombination (HR), a crucial pathway ensuring high-fidelity DNA repair. Recruitment of RAD51 involves eight highly conserved regions on BRCA2, named BRC repeats. The interaction between the fourth BRC repeat (BRC4) and the RAD51

Indexed as

BRCA2 ProteinMolecular Dynamics SimulationRad51 RecombinaseHumansProtein BindingProtein ConformationBRCA2 ProteinRad51 Recombinase

Identifiers

PMID41124105
PMCPMC12606624

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.