Evidence map›Paper›PMID 41124026›Full record

ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2026

Uncovering mechanisms of historical change in midlife loneliness across the United States and Europe: a focus on physical activity, health conditions, and wealth.

Frank J Infurna, Yesenia Cruz-Carrillo, Nutifafa E Y Dey, Markus Wettstein, Kevin J Grimm, Margie E Lachman, Denis Gerstorf

Abstract read
In one paragraph

Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Historical Change in Midlife Development from a Cross-National Perspective.Current directions in psychological science · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Frank J InfurnaDepartment of Psychology, Arizona State University, Tempe, Arizona, United States.ORCID 0000-0002-0690-9253
Yesenia Cruz-CarrilloDepartment of Psychology, Arizona State University, Tempe, Arizona, United States.ORCID 0009-0008-1288-5535
Nutifafa E Y DeyDepartment of Psychology, Arizona State University, Tempe, Arizona, United States.ORCID 0000-0003-4836-2644
Markus WettsteinDepartment of Psychology, Humboldt University Berlin, Berlin, Germany.ORCID 0000-0002-3471-5405
Kevin J GrimmDepartment of Psychology, Arizona State University, Tempe, Arizona, United States.
Margie E LachmanDepartment of Psychology, Brandeis University, Waltham, Massachusetts, United States.ORCID 0000-0003-3027-8735
Denis GerstorfDepartment of Psychology, Humboldt University Berlin, Berlin, Germany.ORCID 0000-0002-2133-9498

Funding

Integrting Information About Aging SurveysR01AG030153 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Sara Adar, Alden L. Gross · 2007 to 2026
$41.7M
Psychosocial Risk and Resilience Mechanisms Underlying Diversity in Midlife Health, Well-Being, and CognitionR01AG079523 · NIA · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI Frank John Infurna · 2022 to 2026
$2.5M
Mega Meta Data Set of the Health and Retirement Surveys Around the WorldRC2AG036619 · NIA · RAND CORPORATION · PI KAPTEYN, ARIE · 2009 to 2010
$2.0M
Archiving & Creating User Friendly Data: the Longitudinal Aging Survey in IndiaR03AG043052 · NIA · RAND CORPORATION · PI LEE, JINKOOK · 2012 to 2012
$95k
NIA NIH HHS R01 AG030153NIA NIH HHS R01 AG079523NIA NIH HHS R03 AG043052NIA NIH HHS RC2 AG036619
6 · The paper itself

Abstract

objectivesPrevious research has observed that U.S. middle-aged adults report higher levels of loneliness than same-aged, earlier-born individuals and exhibit higher overall levels of loneliness relative to their peers in Europe. However, little is known regarding the factors that are driving historical trends in loneliness among middle-aged adults. We investigated the reasons behind these troubling historical trends, with an emphasis on evaluating the mediating role of physical activity, health conditions, and wealth in the United States and Europe.

methodsWe used harmonized data from nationally representative longitudinal panel surveys from the United States and 13 European nations (England and Continental, Mediterranean, and Nordic Europe) to examine whether physical activity, health conditions, and wealth are potential mechanisms that contribute to historical changes in midlife loneliness.

resultsMultilevel mediation models revealed that health conditions consistently mediated links between birth year and loneliness across the nations/regions. Those who showed increases in the number of health conditions were at greater risk for increases in loneliness. Wealth and physical activity mediated historical increases in loneliness in more nation-specific ways. For example, historical declines in wealth accumulation shaped increases in loneliness in the United States, whereas historical improvements in physical activity patterns led to lower levels of loneliness in Nordic Europe. DISCUSSION: Our findings provide initial insights into the potential reasons behind historical trends of loneliness in the United States and European middle-aged adults. Our discussion elaborates on the reasons why physical activity, health conditions, and wealth contribute to historical changes in midlife loneliness.

Indexed as

ExerciseHealth StatusLonelinessAgedEuropeFemaleHumansLongitudinal StudiesMaleMiddle AgedSocioeconomic FactorsUnited StatesCohort differencesCross-national approachMechanismsMidlifeMultilevel mediation

Identifiers

PMID41124026
PMCPMC12759006

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.