ArticleProceedings of the National Academy of Sciences of the United States of America2025
Parallel shifts in differential gene expression reveal convergent miniaturization in fishes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Dynamic body size evolution during speciation of predatory cichlid fishes in the Lake Malawi superradiation.Genome research · 2026Article
- Parallel shifts in differential gene expression reveal convergent miniaturization in fishes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
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4 authors.
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Abstract
Body size variation in vertebrates is a complex polygenic trait, tightly correlated with numerous aspects of a species' biology, ecology, and physiology. Miniaturization, the extreme reduction of adult body size, is a common phenomenon across the Tree of Life, yet the mechanisms underlying this process are poorly understood. Here, we investigate the molecular basis of body size evolution in goby fishes, a clade encompassing some of the smallest vertebrates on Earth. We generate a genome-wide phylogeny for 162 Gobioidei species and perform comparative transcriptomics across three clades with repeated instances of miniaturization and large-bodied forms. We identified 54 differentially expressed one-to-one orthologs between miniature and large-bodied species. These genes reveal distinct functional profiles, suggesting that regulation of cell numbers is a key mechanism governing body size control. Miniature species consistently overexpress growth inhibitors like
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