ArticleJournal of fluorescence2026
MnO
Article in Journal of fluorescence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
8 authors.
Funding
Abstract
Glutathione (GSH), an essential tripeptide with antioxidant, detoxifying, and anti-inflammatory functions, requires rapid and reliable detection in biomedical fields. In this work, orange fluorescent carbon quantum dots (O-CQDs) were created using a hydrothermal method with neutral red and thiourea as precursors. These O-CQDs emit a strong orange fluorescence at 600 nm when excited by UV light, which helps reduce interference from natural fluorescence in biological samples. The fluorescence is effectively quenched by potassium permanganate (KMnO₄) through the in situ generation of manganese dioxide (MnO₂). While GSH is added, it reduces MnO₂ to Mn²⁺, restoring fluorescence via a redox-driven "off-on" mechanism. This approach provides high selectivity and resistance to interference. The O-CQDs have a high quantum yield of 37.19%. The sensor shows a linear detection range from 0 to 100 µM (with the equation F = 34.6327c + 1610.7945) and a detection limit as low as 57 nM. It was successfully used to measure GSH in rabbit serum, achieving recoveries between 93.53% and 102.77% and relative standard deviations (RSD) from 0.71% to 1.72%. This sensor offers easy synthesis, quick response, and high sensitivity, making it a reliable tool for detecting GSH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.