Evidence map›Paper›PMID 41123716›Full record

ArticleJournal of neuro-oncology2025

Stereotactic radiosurgery for patients with brain metastases from nasopharyngeal carcinoma.

David J Puccio, Chris Z Wei, Abhinav Pillai, Hansen Deng, Constantinos G Hadjipanayis, Ajay Niranjan, L Dade Lunsford

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Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

David J PuccioSchool of Medicine, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA, 15213, USA. pucciodj3@upmc.edu.
Chris Z WeiSchool of Medicine, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA, 15213, USA.
Abhinav PillaiSchool of Medicine, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA, 15213, USA.
Hansen DengCenter for Image-Guided Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Constantinos G HadjipanayisCenter for Image-Guided Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Ajay NiranjanCenter for Image-Guided Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
L Dade LunsfordCenter for Image-Guided Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe role of stereotactic radiosurgery (SRS) for patients with brain metastases from nasopharyngeal carcinoma (NPC) has yet to be established. The authors present a single-institution experience of NPC brain metastases patients who underwent SRS.

methodsOur SRS database of 18,000 patients from 1989 to 2024 identified 44 metastatic NPC patients (31 male) with 68 total brain metastases (median age: 58.5 years, range: 33-80). Twenty-four patients underwent whole brain fractionated radiation therapy (WBRT) and 20 patients underwent surgical resection before SRS. The median margin dose was 16 Gy (range: 10-25). The median cumulative tumor volume was 7.6 cubic centimeters (cc) (range: 0.032-186.66).

resultsThe median overall survival (OS) from SRS was 9 months (range: 0-86) with local tumor progression in 11 patients after SRS at a median time of 4 months (range: 2-36). Local tumor control was achieved in 56 of the 68 metastases (82.4%). Five patients developed new brain metastases at a median of 6 months (range: 3-84) following SRS. One patient experienced adverse radiation effects (AREs).

conclusionMetastatic spread to the brain from NPC occurs late in the course of primary disease. In our experience non-invasive SRS optimized outcomes and preserved quality of life. Although historically used as a salvage option after surgery and radiation therapy, its role as a primary strategy deserves further utilization in patients with brain metastases from primary NPC tumors.

Indexed as

Brain NeoplasmsNasopharyngeal NeoplasmsRadiosurgeryAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedNasopharyngeal CarcinomaRetrospective StudiesTreatment OutcomeBrain metastasesLocal tumor controlNasopharyngeal carcinomaOverall survivalPrognostic factorsStereotactic radiosurgery

Identifiers

PMID41123716

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.