Evidence map›Paper›PMID 41123691›Full record

ArticleMarine biotechnology (New York, N.Y.)2025

Versicotide K and Other Secondary Metabolites from the Two Strains of Sponge-Derived Fungi of Aspergillus Genus.

Olga O Khmel, Ekaterina A Yurchenko, Ekaterina A Chingizova, Phan Thi Hoai Trinh, Ngo Thi Duy Ngoc, Vo Thi Dieu Trang, Yulia V Khudyakova, Valeria V Kurilenko, Roman S Popov, Konstantin A Drozdov and 2 more

Abstract read
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In one paragraph

Article in Marine biotechnology (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Olga O KhmelG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 159 Prospect 100-Letiya Vladivostoka, Vladivostok, 690022, Russian Federation.
Ekaterina A YurchenkoG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 159 Prospect 100-Letiya Vladivostoka, Vladivostok, 690022, Russian Federation.
Ekaterina A ChingizovaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 159 Prospect 100-Letiya Vladivostoka, Vladivostok, 690022, Russian Federation.
Phan Thi Hoai TrinhInstitute of Oceanography, Vietnam Academy of Science and Technology, Nha Trang, Viet Nam, 650000.
Ngo Thi Duy NgocInstitute of Oceanography, Vietnam Academy of Science and Technology, Nha Trang, Viet Nam, 650000.
Vo Thi Dieu TrangInstitute of Oceanography, Vietnam Academy of Science and Technology, Nha Trang, Viet Nam, 650000.
Yulia V KhudyakovaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 159 Prospect 100-Letiya Vladivostoka, Vladivostok, 690022, Russian Federation.
Valeria V KurilenkoG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 159 Prospect 100-Letiya Vladivostoka, Vladivostok, 690022, Russian Federation.
Roman S PopovG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 159 Prospect 100-Letiya Vladivostoka, Vladivostok, 690022, Russian Federation.
Konstantin A DrozdovG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 159 Prospect 100-Letiya Vladivostoka, Vladivostok, 690022, Russian Federation.
Alexandr S AntonovG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 159 Prospect 100-Letiya Vladivostoka, Vladivostok, 690022, Russian Federation.
Anton N YurchenkoG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 159 Prospect 100-Letiya Vladivostoka, Vladivostok, 690022, Russian Federation. yurchenkoan@piboc.dvo.ru.

Funding

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Science No. 075-03-2025-231Oceanography, Vietnam Academy of Science and Technology CSCL18.02/25-26
6 · The paper itself

Abstract

The unreported peptide versicotide K (1), along with known averufin (2), 1'- hydroxyversicolorin B (3), averufanin (4), and sterigmatocystin (5), was isolated from the sponge-derived fungal strain Aspergillus versicolor 01NT- 1.5.1. Moreover, the new 6,8-dimethoxyaverythrin (6) and known averythrin (7) and sclerotiotide F (8) were isolated from another sponge-derived fungus Aspergillus flavus КMM 4695 (= VO49-48.3). The antimicrobial and cytotoxic activities of the isolated compounds were studied. The obtained data on the low cytotoxicity of averufanin (4) to normal HaCaT keratinocytes and H9c2 cardiomyocytes confirms its anticancer potential for future research. The significant activity of averythrin (7) against Staphylococcus aureus growth and biofilm formation (IC

Indexed as

AspergillusAspergillus flavusPoriferaAnimalsAnti-Inflammatory AgentsBiofilmsCell LineCyclooxygenase 2HaCaT CellsHumansKeratinocytesMolecular Docking SimulationMyocytes, CardiacRatsSecondary MetabolismStaphylococcus aureusAnti-Inflammatory AgentsCyclooxygenase 2Anti-inflammatory propertiesAntimicrobial activityAspergillusCytotoxic activityCytotoxicitySecondary metabolites

Identifiers

PMID41123691

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.