Evidence map›Paper›PMID 41123659›Full record

Observational studyGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026

Different retinal microvascular response to flicker light between normal-tension glaucoma and high-tension primary open-angle glaucoma detected with optical coherence tomography angiography.

Ruirong You, Xingyu Zhou, Xiaowei Xu, Wenjing Wang, Daokuan Yu, Xinyi Fang, Yuanbo Liang, Dexi Zhu, Shaodan Zhang

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Ruirong YouThe Eye Hospital of Wenzhou Medical University, Glaucoma Research Institute of Wenzhou Medical University, No.270 Xueyuanxi Street, Lucheng District, Wenzhou, 325027, Zhejiang, China.
Xingyu ZhouThe Eye Hospital of Wenzhou Medical University, Glaucoma Research Institute of Wenzhou Medical University, No.270 Xueyuanxi Street, Lucheng District, Wenzhou, 325027, Zhejiang, China.
Xiaowei XuThe Eye Hospital of Wenzhou Medical University, Glaucoma Research Institute of Wenzhou Medical University, No.270 Xueyuanxi Street, Lucheng District, Wenzhou, 325027, Zhejiang, China.
Wenjing WangThe Eye Hospital of Wenzhou Medical University, Glaucoma Research Institute of Wenzhou Medical University, No.270 Xueyuanxi Street, Lucheng District, Wenzhou, 325027, Zhejiang, China.
Daokuan YuThe Eye Hospital of Wenzhou Medical University, Glaucoma Research Institute of Wenzhou Medical University, No.270 Xueyuanxi Street, Lucheng District, Wenzhou, 325027, Zhejiang, China.
Xinyi FangThe Eye Hospital of Wenzhou Medical University, Glaucoma Research Institute of Wenzhou Medical University, No.270 Xueyuanxi Street, Lucheng District, Wenzhou, 325027, Zhejiang, China.
Yuanbo LiangThe Eye Hospital of Wenzhou Medical University, Glaucoma Research Institute of Wenzhou Medical University, No.270 Xueyuanxi Street, Lucheng District, Wenzhou, 325027, Zhejiang, China.
Dexi ZhuThe Eye Hospital of Wenzhou Medical University, Glaucoma Research Institute of Wenzhou Medical University, No.270 Xueyuanxi Street, Lucheng District, Wenzhou, 325027, Zhejiang, China. zhudexi@wmu.edu.cn.
Shaodan ZhangThe Eye Hospital of Wenzhou Medical University, Glaucoma Research Institute of Wenzhou Medical University, No.270 Xueyuanxi Street, Lucheng District, Wenzhou, 325027, Zhejiang, China. shaodan_zhang@eye.ac.cn.ORCID http://orcid.org/0000-0002-3655-0683

Funding

National Natural Science Foundation of China 82070958Science and Technology Program of Zhejiang Province 2021KY811
6 · The paper itself

Abstract

purposeTo compare the visual task-evoked microvascular response in the macula between normal-tension glaucoma (NTG) and high-tension primary open-angle glaucoma [i.e., high-tension glaucoma (HTG)] by using optical coherence tomography angiography (OCTA).

methodsIn this case-control observational study, ten eyes of 10 patients with HTG, twelve eyes of 12 patients with NTG and eleven eyes of 11 healthy participants were included. All glaucoma eyes had a preserved central visual field of at least 10° and best corrected visual acuity of 20/40 or better. Macular superficial vessel density (VD) was measured by OCTA at baseline and then immediately after a 12.5 Hz white light flicker stimulation.

resultsFlicker light stimulation evoked significant increase in macular superficial VD of HTG (baseline vs. poststimulation:35.31% ± 4.31% vs. 36.07% ± 4.35%, P = 0.048) and control eyes (46.21% ± 2.94% vs. 47.09% ± 2.68%, P = 0.028) but not the eyes with NTG (37.98% ± 5.99% vs. 37.44% ± 5.69%, P = 0.622). The absolute change in VD (ΔVD) was significantly smaller in NTG eyes compared to control eyes (-0.54% ± 1.40% vs. 0.88% ± 1.14%, P = 0.026). NTG eyes also had a lower VD change percentage in the temporal macula than that in HTG eyes (-1.17% ± 5.53% vs. 4.01% ± 4.73%, P = 0.042).

conclusionsVisual task-evoked vasoreactivity changes provide additional information in the understanding and assessment of the pathophysiological mechanisms of glaucoma. Discrepancies in the retinal vasoreactivity between HTG and NTG imply that vascular factors may play different roles in the onset and progression of these diseases. KEY MESSAGES: What is known Vessel density (VD) of the macular superficial retina has been proven to be reduced in individuals suffering from primary open-angle glaucoma (POAG). The reduction of VD has been found to be correlated with the progressive development of glaucoma. What is new Patients with normal-tension glaucoma (NTG) has impaired vasoreactivity to visual stimulation compared with high-tension POAG. The visual stimulation-assisted dynamic optical coherence tomography angiography (OCTA) technique can provide additional information for the vascular dysregulation in the pathophysiology of subtypes of POAG.

Indexed as

Fluorescein AngiographyGlaucoma, Open-AngleIntraocular PressureLow Tension GlaucomaMacula LuteaMicrovesselsRetinal VesselsTomography, Optical CoherenceVisual FieldsAgedCase-Control StudiesFemaleFollow-Up StudiesFundus OculiHumansMaleNeurovascular couplingOptical coherence tomography angiographyPrimary open-angle glaucomaVasoreactivity

Identifiers

PMID41123659

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.