Evidence map›Paper›PMID 41123653›Full record

ArticlePediatric nephrology (Berlin, Germany)2026

Neonatal acute kidney disease in the National Center for Child Health and Development (NCCHD)-neoAKI cohort: risk factors and prognostic outcomes.

Kentaro Nishi, Kana Fukui, Toshihiro Matsui, Satoshi Okada, Tatsuki Ikuse, Yurina Miyata, Hiroyuki Aiba, Hirotaka Chiba, Takanori Funaki, Tetsuya Isayama and 2 more

Abstract read
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In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kentaro NishiDivision of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-Ku, Tokyo, 157-8535, Japan. nishi-k@ncchd.go.jp.ORCID http://orcid.org/0000-0002-3436-0392
Kana FukuiDivision of Neonatology, Center for Maternal-Fetal Neonatal and Reproductive Medicine, NCCHD, Tokyo, Japan.
Toshihiro MatsuiDivision of Infectious Diseases, Department of Medical Subspecialties, NCCHD, Tokyo, Japan.
Satoshi OkadaDivision of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-Ku, Tokyo, 157-8535, Japan.
Tatsuki IkuseDivision of Infectious Diseases, Department of Medical Subspecialties, NCCHD, Tokyo, Japan.
Yurina MiyataDivision of Neonatology, Center for Maternal-Fetal Neonatal and Reproductive Medicine, NCCHD, Tokyo, Japan.
Hiroyuki AibaDivision of Infectious Diseases, Department of Medical Subspecialties, NCCHD, Tokyo, Japan.
Hirotaka ChibaDepartment of Information Technology and Management, NCCHD, Tokyo, Japan.
Takanori FunakiDivision of Infectious Diseases, Department of Medical Subspecialties, NCCHD, Tokyo, Japan.
Tetsuya IsayamaDivision of Neonatology, Center for Maternal-Fetal Neonatal and Reproductive Medicine, NCCHD, Tokyo, Japan.
Yushi ItoDivision of Neonatology, Center for Maternal-Fetal Neonatal and Reproductive Medicine, NCCHD, Tokyo, Japan.
Koichi KameiDivision of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-Ku, Tokyo, 157-8535, Japan.

Funding

National Center for Child Health and Development 2024B-9
6 · The paper itself

Abstract

backgroundAcute kidney disease (AKD) is defined as kidney dysfunction lasting 7-90 days after the onset of acute kidney injury (AKI). Although widely recognized in adults and children, its significance in neonates is unclear. We aimed to investigate the risk factors and outcomes of neonatal AKD in a cohort of neonates with AKI.

methodsWe performed a retrospective cohort study at a tertiary NICU in Japan. Among 345 neonates with AKI between 2014 and 2024, 280 were included after excluding cases with congenital kidney disease, early death (< 7 days), or missing data. AKD was defined by KDIGO/ADQI criteria. We compared clinical features and outcomes between neonates with and without AKD and used multivariable logistic regression to identify predictors.

resultsOf 280 neonates with AKI, 85 (30%) developed AKD. Compared to non-AKD neonates, those with AKD had higher 90-day mortality (8% vs. 2%, P = 0.005) and MAKE90 (17% vs. 7%, P = 0.014). Chronic lung disease (78% vs. 50%, P < 0.001) and intraventricular hemorrhage (38% vs. 16%, P = 0.002) were also more common in the AKD group. In multivariable analysis, aminoglycoside exposure (OR = 2.04; 95% CI, 1.07-4.04; P = 0.031) and lower birth weight (per 100 g) (OR = 2.73; 95% CI, 1.11-1.22; P = 0.002) were independently associated with AKD.

conclusionNeonatal AKD was common and associated with increased mortality and major adverse kidney events. Our findings support AKD as a useful concept for identifying high-risk neonates and highlight the need for long-term kidney monitoring in this vulnerable population.

Indexed as

Acute Kidney InjuryFemaleHumansInfant, NewbornIntensive Care Units, NeonatalJapanMalePrognosisRetrospective StudiesRisk FactorsAcute kidney injuryChildrenChronic kidney diseaseNeonateNephrotoxic medicationsNICU

Identifiers

PMID41123653

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.