Evidence map›Paper›PMID 41123652›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2025

Long-pulsed 1064-nm neodymium: yttrium-aluminum-garnet laser alleviates rosacea by improving lymphatic vessel dysfunction.

Duoduo Gu, Ruoxin Pan, Tingwei Liu, Xiaoqi Meng, Qin Ye, Chaoli Hong, Changlin Sun, Yi Wang, Wanqing Yang, Nuoran Chen and 2 more

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Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Duoduo GuDepartment of Dermatology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.
Ruoxin PanDepartment of Dermatology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.
Tingwei LiuDepartment of Dermatology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.
Xiaoqi MengDepartment of Dermatology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.
Qin YeForensic Identification Institute, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.
Chaoli HongDepartment of Operative Dentistry and Endodontics, Changzhou Stomatological Hospital, Changzhou Hospital of Traditional Chinese Medicine, Changzhou hospital affiliated to Nanjing University of Chinese Medicine, Changzhou, Jiangsu, China.
Changlin SunDepartment of Pharmacology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China.
Yi WangDepartment of Pharmacology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China.
Wanqing YangDepartment of Dermatology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.
Nuoran ChenDepartment of Dermatology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.
Wentao LiuJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, China. painresearch@njmu.edu.cn.
Yang XuDepartment of Dermatology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China. yangxu@njmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

OBJECTIVE AND

designWe aimed to investigate potential lymphatic vessel abnormalities associated with rosacea and elucidate effective rosacea treatment mechanism using long-pulsed 1064-nm neodymium: yttrium-aluminum-garnet laser (LPND). MATERIAL OR SUBJECTS: 32 female BALB/c mice were used to established the rosacea-like inflammation model and LPND treatment model. Human lymphatic endothelial cells (HLECs) were used for in vitro studies. TREATMENT: LL37 and/or LPND treatment.

methodsTranscriptomic analyses and clinical observation were performed. Techniques such as Western blotting, immunofluorescence staining, flow cytometry, and clearance assays were employed to assess characteristics of lymphatic vessels. Statistical comparisons between two groups were conducted using Student's t-test or the Mann-Whitney U test, while comparisons among more than two groups were analyzed using one-way or two-way analysis of variance (ANOVA).

resultsIndividuals with rosacea exhibited lymphatic dysfunction and LPND treatment could alleviate rosacea-associated clinical edema. Comparative analyses of acute and chronic mouse models revealed lymphatic vessel dilation, reduced density, and impaired function in chronic rosacea-like inflammation. LPND treatment mitigated chronic rosacea-like inflammation by ameliorating lymphatic vessel abnormalities. In vitro experiments demonstrated that LPND attenuated LL-37-induced inflammatory responses in HLECs.

conclusionsWe elucidated the abnormalities of lymphatic vessels in rosacea and provided evidence supporting the targeted lymphatic vessel therapies.

Indexed as

Lasers, Solid-StateLow-Level Light TherapyLymphatic VesselsRosaceaAdultAnimalsAntimicrobial Cationic PeptidesCathelicidinsDisease Models, AnimalEndothelial CellsFemaleHumansMiceMice, Inbred BALB CAntimicrobial Cationic PeptidesCathelicidinsEtiologyLaser therapyLymphatic vesselsLymphedemaRosacea

Identifiers

PMID41123652

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.