Evidence map›Paper›PMID 41123639›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Heart failure in old hypertensive rats is accompanied by the increase of neutrophil extracellular traps and myeloid-derived suppressor cells.

V Polishchuk, D Pashevin, B Dons'koi, T Lapikova-Bryhinska, G Portnichenko, T Drevytska, V Nagibin, V Dosenko

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

V PolishchukDepartment of General and Molecular Pathophysiology, Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
D PashevinDepartment of General and Molecular Pathophysiology, Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
B Dons'koiVictor Chernyshov Laboratory of Immunology, State Institution "Ukrainian Center of Maternity and Childhood", National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine.
T Lapikova-BryhinskaDepartment of General and Molecular Pathophysiology, Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
G PortnichenkoDepartment of General and Molecular Pathophysiology, Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
T DrevytskaDepartment of General and Molecular Pathophysiology, Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
V NagibinDepartment of General and Molecular Pathophysiology, Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine. nagibin@biph.kiev.ua.ORCID http://orcid.org/0000-0001-6259-0518
V DosenkoDepartment of General and Molecular Pathophysiology, Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine.

Funding

National Research Foundation of Ukraine 2020.01/0517
6 · The paper itself

Abstract

Arterial hypertension (AH) and heart failure (HF) are age-associated conditions usually accompanied by chronic inflammation. Neutrophil extracellular traps (NET) are important during inflammation and left ventricular remodeling but their functions in HF are poorly studied. Myeloid-derived suppressor cells (MDSC) that fulfill anti-inflammatory functions are also not studied during HF. The goal of this work is to evaluate the balance between proinflammatory NET-producing neutrophils and anti-inflammatory MDSC in pathogenesis of AH and HF in elder rats. Wistar and spontaneously hypertensive rats (SHR) aged 5 and 16 months were subjected to cardiodynamic parameters monitoring. NET formation was examined using fluorescence microscopy. MDSC were determined as CD11b/c

Indexed as

AgingExtracellular TrapsHeart FailureHypertensionMyeloid-Derived Suppressor CellsNeutrophilsAnimalsMaleRatsRats, Inbred SHRRats, WistarAgingArterial hypertensionHeart failureMyeloid-derived suppressor cellsNeutrophil extracellular traps

Identifiers

PMID41123639

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.