ArticleBioconjugate chemistry2025
Probing the Broad-Spectrum Virus-Neutralizing Epitopes Using the High-Density Oligomannose-Conjugates and Carbohydrate Microarrays.
Article in Bioconjugate chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Following global efforts to decipher the glycome of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), we further explored the immunologically potent carbohydrates in the viral glycan shield. Specifically, we constructed a large panel of glycoconjugates, utilizing soluble protein carriers and bacteriophage Qβ viral-like particles (Qβ-VLPs) to display oligomannoses in multiple cluster configurations for immune recognition. Using a broad-spectrum virus-neutralizing agent, Galanthus nivalis agglutinin (GNA), and SARS-CoV-2-neutralizing antisera elicited in nonhuman primates (NHPs), we performed a carbohydrate-microarray-based glyco-epitope-mapping analysis of these synthetic glyco-conjugates. We found that several oligomannose-conjugates, including members of the Bovine Serum Albumin (BSA)- and Qβ-series of high-mannose-conjugates, reestablished the GNA epitopes with potency comparable to that of those expressed by the native viral glycoproteins. However, the NHP antisera differentially react with these glyco-conjugates and exhibit high selectivity for the GNA
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