ArticleCell cycle (Georgetown, Tex.)
Transcriptional cyclin-dependent kinases Cdk8 and Cdk19 are required for normal macrophage differentiation.
Aleksandra Kolodziejczyk, Samantha Liu, Fabian Strobel, Diego Martinez Alonso, Deborah Butter, Konrad Śnioch, Chen Chu, Henry Long, Veronika Sexl, Li Qiang and 2 more
Abstract read
In one paragraphArticle in Cell cycle (Georgetown, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Aleksandra KolodziejczykDepartment of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-1929-5254 Samantha LiuDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute and Department of Immunology, Harvard Medical School, Boston, MA, USA.ORCID 0009-0007-6837-5860 Fabian StrobelDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute and Department of Immunology, Harvard Medical School, Boston, MA, USA.ORCID 0009-0005-8751-4606 Diego Martinez AlonsoDepartment of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0521-5134 Deborah ButterDepartment of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-1714-4049 Konrad ŚniochDepartment of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA, USA.
Chen ChuDepartment of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8084-0867 Veronika SexlInstitute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Vienna, Austria.ORCID 0000-0001-9363-0412 Li QiangDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute and Department of Immunology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2354-177X Stephanie K DouganDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute and Department of Immunology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2263-363X Piotr SicinskiDepartment of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8859-5234 Funding
Cyclin C-CDK8/19 kinases in development and in cancerR01CA269285 · NCI · DANA-FARBER CANCER INST · PI Peter Sicinski · 2022 to 2026
$2.6MCDK4/6 inhibition during CD8 T cell priming potentiates memory formation in mice and humansR01AI158488 · NIAID · DANA-FARBER CANCER INST · PI DOUGAN, STEPHANIE · 2021 to 2025
$2.2MNew approaches to targeting cell cycle proteins for cancer treatmentR35CA305086 · NCI · DANA-FARBER CANCER INST · PI Peter Sicinski · 2025 to 2026
$1.7MNCI NIH HHS R01 CA269285NCI NIH HHS R35 CA305086NIAID NIH HHS R01 AI158488
6 · The paper itselfAbstract
Cyclin-dependent kinases CDK8 and CDK19 together with their activating partner, cyclin C, regulate gene expression as a part of the Mediator complex and by phosphorylating DNA sequence-specific transcription factors. Here, we investigated the
Indexed as
Cell DifferentiationCyclin-Dependent Kinase 8Cyclin-Dependent KinasesMacrophagesTranscription, GeneticAnimalsHematopoiesisMiceMice, Inbred C57BLMice, KnockoutPhagocytosisCdk8 protein, mouseCyclin-Dependent Kinase 8Cyclin-Dependent KinasesCdk19Cdk8Cyclin-dependent kinaseshematopoiesismacrophage
Identifiers
PMID41123539
PMCPMC12918288
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