Evidence map›Paper›PMID 41123535›Full record

ArticleJACC. Case reports2025

Mitral Annular Subvalvular Aneurysm With Leaflet Perforation and Left Atrium-to-Left Ventricle Fistulous Communication.

Daniela Harsanyi, Ana Carolina Loayza Benchimol Barbosa, Jessica Silva Nicolau, José Roberto de Oliveira Silva Filho, Léa Maria Macruz Ferreira Demarchi, Antonio de Santis, Elinthon Tavares Veronese, Carlos Manuel de Almeida Brandão, Flávio Tarasoutchi, Paulo Rogério Soares and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Daniela HarsanyiEmergency Department, Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Ana Carolina Loayza Benchimol BarbosaEmergency Department, Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Jessica Silva NicolauEmergency Department, Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
José Roberto de Oliveira Silva FilhoEmergency Department, Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Léa Maria Macruz Ferreira DemarchiEmergency Department, Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Antonio de SantisEmergency Department, Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Elinthon Tavares VeroneseEmergency Department, Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Carlos Manuel de Almeida BrandãoEmergency Department, Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Flávio TarasoutchiEmergency Department, Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Paulo Rogério SoaresEmergency Department, Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Thiago Luis ScudelerEmergency Department, Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. Electronic address: thiago.scudeler@fm.usp.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMitral annular subvalvular aneurysm (MASA) is a rare cardiac condition with variable etiology and potentially life-threatening complications. CASE SUMMARY: A 35-year-old previously healthy man of African descent presented with progressive dyspnea and weight loss. Multimodality imaging revealed a posterior MASA complicated by leaflet perforation, left atrium-to-left ventricle fistula, and severe mitral regurgitation. Despite negative microbiological and histological results, morphological and intraoperative findings strongly suggested healed infective endocarditis rather than a congenital origin. Urgent mitral valve replacement with aneurysm exclusion was successfully performed. DISCUSSION: This case highlights the diagnostic and surgical value of multimodality imaging-including echocardiography, cardiac computed tomography, and magnetic resonance-in confirming MASA and supporting an acquired inflammatory etiology when infectious work-up is inconclusive. TAKE-HOME MESSAGES: MASA secondary to healed endocarditis should be suspected in the presence of leaflet perforation, atrioventricular fistula, and severe mitral regurgitation. Comprehensive multimodality imaging is essential for diagnosis and surgical planning.

Indexed as

cardiac computed tomographyechocardiographyendocarditismagnetic resonancemitral regurgitationmitral subvalvular aneurysm

Identifiers

PMID41123535
PMCPMC12714510

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.