Evidence map›Paper›PMID 41123520›Full record

ArticleJournal of the American College of Cardiology2025

Combining Polygenic Risk With LDL, CRP, and Lp(a) to Predict Coronary Artery Disease: UK Biobank Study.

Sumeet A Khetarpal, Zhuqing Shi, Aman Goyal, Aniruddh P Patel, Sarah M Urbut, Christie M Ballantyne, Pradeep Natarajan, Amit V Khera, Jianfeng Xu, Arman Qamar

Abstract read
In one paragraph

Article in Journal of the American College of Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sumeet A KhetarpalDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts, USA. Electronic address: sumeet.khetarpal@gmail.com.
Zhuqing ShiProgram for Genomic Translational Research, NorthShore University HealthSystem (Endeavor Health), Evanston, Illinois, USA.
Aman GoyalDepartment of Internal Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Aniruddh P PatelDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
Sarah M UrbutDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
Christie M BallantyneSection of Cardiovascular Research, Department of Medicine, Texas Heart Institute at Baylor College of Medicine, Houston, Texas, USA.
Pradeep NatarajanDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
Amit V KheraDivision for Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA; Verve Therapeutics, Boston, Massachusetts, USA.
Jianfeng XuProgram for Genomic Translational Research, NorthShore University HealthSystem (Endeavor Health), Evanston, Illinois, USA.
Arman QamarProgram for Genomic Translational Research, NorthShore University HealthSystem (Endeavor Health), Evanston, Illinois, USA; Center for Cardiovascular Personalized Medicine, Section of Interventional Cardiology and Vascular Medicine, Endeavor Health Cardiovascular Institute, Glenview, Illinois, USA. Electronic address: aqamar@northshore.org.

Funding

Advancing the clinical actionability of polygenic scores for coronary artery diseaseK08HL168238 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Aniruddh Patel · 2024 to 2026
$511k
Discovery of Heart-Derived Myokines Mediating the Response to Exercise Stress Via PGC-1aK08HL177169 · NHLBI · UNIVERSITY OF VIRGINIA · PI Sumeet Khetarpal · 2025 to 2026
$286k
NHLBI NIH HHS K08 HL168238NHLBI NIH HHS K08 HL177169
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

biomarkercoronary artery diseasehigh-sensitivity C-reactive proteinlipoprotein(a)low-density lipoprotein cholesterolpolygenic riskrisk-enhancing factor

Identifiers

PMID41123520
PMCPMC13654585

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.