ArticleClinical transplantation2025
Reduced Functional Status among Kidney Transplant Recipients over Time and Associated Risks Post-Transplant.
Article in Clinical transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Reduced Functional Status among Kidney Transplant Recipients over Time and Associated Risks Post-Transplant.Clinical transplantation · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReduced functional status (RFS) has been associated with death and graft loss after kidney transplant; whether the risk of short-term outcomes, including delayed graft function (DGF) and early graft loss (EGL) is also increased is unknown. The purpose of this study was to examine whether RFS is associated with DGF, EGL, and all-cause graft loss (ACGL) in kidney transplant recipients (KTRs; overall and by recipient age, sex, race, donor status, and transplant era).
methodsSeparately among adult living and deceased donor KTR in the United States identified using the SRTR (2000-2017), multivariable logistic regression and Cox proportional hazards models were used as appropriate to examine the association of RFS (Karnofsky Performance Status [KPS] ≤50%; requires considerable or greater assistance) relative to functional independence (KPS 80%-100%) at the time of kidney transplant with the outcomes of DGF, EGL, and ACGL. Whether recipient age, sex, race, donor status, or transplant era modified the risk of RFS associated with each outcome was also examined.
resultsAmong 245 446 KTR, RFS at transplant was associated with increased risk of DGF (aOR 1.47, 95% CI 1.36-1.59), EGL (aOR 2.85, 95% CI 2.52-3.24), and ACGL (aHR 1.21, 95% CI 1.14-1.28) in deceased donor KTR, and increased risk of DGF (aOR 1.32, 95% CI 1.01-1.73), EGL (aOR 2.07, 95% CI 1.48-2.89), and ACGL (aHR 1.24, 95% CI 1.11-1.38) in living donor KTR compared to those with functional independence. In deceased donor KTR, the risk of DGF was modified by recipient age, sex, and race, and the risk of EGL was modified by sex. In living donor KTR, the risk of DGF was modified by age, and the risk of ACGL was modified by sex.
conclusionsRFS at transplant has increased over time and is associated with increased risk of DGF, EGL, and ACGL; recipient characteristics modify these risks.
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