Evidence map›Paper›PMID 41123088›Full record

ArticleJournal of the American Chemical Society2025

Hypochlorous Acid-Gated Hydrolysis of a Phosphinate Ester Dye in Living Cells.

Yuan Fang, Xinqi Zhou, Julia L McAfee, Benjamin M Faulkner, Lauren Lesiak, Yuchen He, Frederik Bro̷ndsted, Hao Fan, Eric D Donarski, Xiaoyan Hu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yuan FangDepartment of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.ORCID 0000-0003-1987-0885
Xinqi ZhouDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, United States.
Julia L McAfeeDepartment of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.
Benjamin M FaulknerDepartment of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.
Lauren LesiakDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, United States.ORCID 0000-0001-6254-7085
Yuchen HeDepartment of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.
Frederik Bro̷ndstedDepartment of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.ORCID 0000-0001-8402-2562
Hao FanDepartment of Medicine, University of Virginia, Charlottesville, Virginia 22904, United States.
Eric D DonarskiDepartment of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.
Xiaoyan HuDivision of Hematology/Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298, United States.
B Jill VentonDepartment of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.ORCID 0000-0002-5096-9309
Steven GrantDivision of Hematology/Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298, United States.
Francine E Garrett-BakelmanDepartment of Medicine, University of Virginia, Charlottesville, Virginia 22904, United States.
Cliff I StainsDepartment of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.ORCID 0000-0002-3165-4539

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Thomas P. Loughran · 1987 to 2026
$72.1M
Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Keri R Maher · 1985 to 2026
$51.0M
Princess Margaret Phase I Consorium (PMP1C)UM1CA186644 · NCI · UNIVERSITY HEALTH NETWORK · PI Philippe Bedard, Kevin D Courtney · 2014 to 2026
$16.6M
Multiplexed neurochemical methods to understand adenosine neuromodulationR01NS121014 · NINDS · UNIVERSITY OF VIRGINIA · PI B. JILL VENTON · 2022 to 2026
$3.0M
Chemical Approaches for Interrogating Fundamental Biomedical ProcessesR35GM148221 · NIGMS · UNIVERSITY OF VIRGINIA · PI Cliff I Stains · 2023 to 2026
$1.6M
Leica tauSTED super resolution microscopy for molecular imaging in fixed and live specimensS10OD030409 · OD · UNIVERSITY OF VIRGINIA · PI PERIASAMY, AMMASI · 2022 to 2022
$850k
NCI NIH HHS P30 CA016059NCI NIH HHS P30 CA044579NCI NIH HHS UM1 CA186644NIGMS NIH HHS R35 GM148221NIH HHS S10 OD030409NINDS NIH HHS R01 NS121014
6 · The paper itself

Abstract

Theranostic fluorescent platforms are capable of the selective delivery of small molecules to target cells with simultaneous optical monitoring. Such technologies promise to significantly reduce off-target effects compared with cytotoxic chemotherapy. However, small-molecule approaches are often hindered by relatively complex designs that are required to incorporate a fluorescent reporter, reactive linker, targeting ligand, and cargo into a single molecule. Herein, we provide the first direct evidence for the ability to gate the delivery of small-molecule cargos from phosphinate ester-containing Nebraska Red (

Indexed as

Fluorescent DyesHypochlorous AcidAnimalsEstersHumansHydrolysisLeukemia, Myeloid, AcuteMolecular StructurePhosphinic AcidsEstersFluorescent DyesHypochlorous AcidPhosphinic Acids

Identifiers

PMID41123088
PMCPMC12588358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.