Investigating the effects of circadian rhythm on the human skin lipidome.

Caroline Géhin, Amanda V Witter, Lu Wang, Perdita E Barran, Stephen J Fowler, Drupad K Trivedi

Abstract read

In one paragraph

Article in The Analyst, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Caroline GéhinMichael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester, Princess Street, Manchester M1 7DN, UK. drupad.trivedi@manchester.ac.uk.ORCID http://orcid.org/0000-0003-4600-8633

Amanda V WitterMichael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester, Princess Street, Manchester M1 7DN, UK. drupad.trivedi@manchester.ac.uk.ORCID http://orcid.org/0009-0009-0137-741X

Lu WangMichael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester, Princess Street, Manchester M1 7DN, UK. drupad.trivedi@manchester.ac.uk.

Perdita E BarranMichael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester, Princess Street, Manchester M1 7DN, UK. drupad.trivedi@manchester.ac.uk.ORCID http://orcid.org/0000-0002-7720-586X

Stephen J FowlerFaculty of Biology, Medicine and Health, School of Biological Sciences, University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-4524-1663

Drupad K TrivediMichael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester, Princess Street, Manchester M1 7DN, UK. drupad.trivedi@manchester.ac.uk.ORCID http://orcid.org/0000-0001-7969-0195

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The circadian rhythm is a 24 h cycle that harmonises the activity of organs - including the skin - to a daily routine using neurological and hormonal signals. Limited research has been done to understand the effects of the circadian rhythm on the skin lipidome. We used reversed-phase liquid chromatography-mass spectrometry (RPLC-MS) in a longitudinal study to investigate temporal changes to the skin lipidome over a 24 h cycle for eight healthy participants. All statistical analyses were performed with a group-mean and individual-mean data approach. Using cosinor analysis

Indexed as

Circadian RhythmLipidomicsSkinAdultChromatography, Reverse-PhaseFemaleHumansMaleMass SpectrometryYoung Adult

Identifiers

PMID41123045

DOI10.1039/d5an00665a

PMCPMC12541903

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.