SynthesisEuropean journal of neurology2025
Association Between Migraine and Periodontitis: A Systematic Review and Meta-Analysis.
Synthesis in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Association Between Migraine and Periodontitis: A Systematic Review and Meta-Analysis.European journal of neurology · 2025Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMigraine is a global public health burden, with characteristics of stabbing pain, hypersensitivity and vegetative symptoms, affecting one billion people with multiple risk factors and potential pathophysiological mechanisms, including neuroinflammation. Periodontitis is a multifactorial disease that affects the dental supporting tissues (gingiva, periodontal ligament, root cementum, and alveolar bone), which in advanced stages can cause tooth loss. This pathology can have systemic implications, and its association with migraine offers a promising area of research to understand and treat both conditions. The aim of this study was to review the scientific evidence that links both pathologies. MATERIAL AND
methodsA systematic review and meta-analysis was carried out using four databases (PubMed, Web of Science, Scopus, and Embase). A total of 197 articles were retrieved; after applying the selection criteria, a total of 8 articles were included in the review and 6 in the meta-analysis, which were combined using the Random Forest model.
resultsAn OR of 1.8 with a 95% confidence interval = 1.4-2.32 was estimated. The meta-analysis showed a significant OR by Z-test = 4.55 (p < 0.001). Regarding publication bias, an intercept was obtained using Egger's regression method equivalent to 2.83 with a 95% confidence interval = 1.31-4.36 (p = 0.007). After qualitative analysis, we found risk factors (such as smoking and stress) and comorbidities (obesity, diabetes, hormonal disorders, among others) that could be involved in this association.
conclusionsThrough this meta-analysis, we have seen how there is a statistically significant relationship between periodontitis and migraine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.