Evidence map›Paper›PMID 41122832›Full record

Observational studyTransfusion2025

Global transfusion practices in septic patients in the intensive care unit: insights from the InPUT-study sub-analysis.

Vincent C Kurucz, Andrew W J Flint, Alexis Poole, Merijn C Reuland, Claudia van den Oord, Caroline M Schaap, Jan Bakker, Maurizio Cecconi, Aarne Feldheiser, Jens Meier and 34 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Transfusion, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors.

Vincent C KuruczDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Andrew W J FlintTransfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Alexis PooleThe Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Merijn C ReulandDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, The Netherlands.ORCID https://orcid.org/0009-0009-3738-0397
Claudia van den OordDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Caroline M SchaapDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Jan BakkerDepartment of Intensive Care Adults, Erasmus MC University Medical Centers, Rotterdam, The Netherlands.
Maurizio CecconiDepartment of Anesthesiology and Intensive Care, IRCCS Humanitas Research Hospital, Milan, Italy.
Aarne FeldheiserDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, EvangKliniken Essen-Mitte, Huyssens-Stiftung/Knappschaft, Essen, Germany.ORCID https://orcid.org/0000-0002-0014-8879
Jens MeierDepartment of Anesthesiology and Intensive Care, Kepler University Clinic, Kepler University, Linz, Austria.
Zoe McQuiltenTransfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.ORCID https://orcid.org/0000-0001-9698-7185
Marcella C A MüllerDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Sanne de BruinDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Thomas W L ScheerenDepartment of Anesthesiology, University Medical Center Groningen, Groningen, The Netherlands.
Tarikul HamidDepartment of Critical Care, Asgar Ali Hospital, Dhaka, Bangladesh.
Cécile AubronMédecine Intensive Réanimation, CHU de Brest, Université de Bretagne Occidentale, Brest, France.
Michaël PiagnerelliDepartment of Intensive Care, CHU Charleroi Marie Curie, Université Libre de Brussels, Charleroi, Belgium.
Tina Tomić MahečićDepartment of Anesthesiology and Intensive Care, University Clinical Hospital Center Zagreb, Zagreb, Croatia.ORCID https://orcid.org/0000-0003-2470-6238
Jan BenesDepartment of Anesthesiology and Intensive Care Medicine, University Hospital and Faculty of Medicine in Plzen-Charles University, Plzen, Czech Republic.
Lene RussellDepartment of Intensive Care, Copenhagen University Hospital, Rigshospitalet Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-7352-8728
Hernan Aguirre-BermeoUnidad de Cuidados Intensivos, Hospital Vicente Corral Moscoso, Cuenca, Ecuador.
Konstantina TriantafyllopoulouDepartment of Cardiothoracic Surgery, European Interbalkan Medical Center, Thessaloniki, Greece.
Vasiliki ChantziaraIntensive Care Unit, First Department of Respiratory Medicine, National and Kapodistrian University of Athens, Sotiria Chest Hospital, Athens, Greece.
Mohan GurjarDepartment of Critical Care Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Sheila Nainan MyatraDepartment of Anesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India.
Vincenzo PotaDepartment of Child, General and Specialistic Surgery, University of Campania, Luigi Vanvitelli, Naples, Italy.ORCID https://orcid.org/0000-0001-9999-3388
Muhammed ElhadiFaculty of Medicine, University of Tripoli, Tripoli, Libya.
Ryszard GawdaDepartment of Anesthesiology and Intensive Care, Institute of Medical Sciences, University of Opole, Opole, Poland.ORCID https://orcid.org/0000-0001-6060-0751
Mafalda MouriscoDepartment of Intensive Care, Centro Hospitalar de Entro o Douro e Vouga, Santa Maria da Feira, Portugal.
Marcus LanceDepartment of Anesthesiology, Aga Khan University Hospital, Nairobi, Kenya.
Vojislava NeskovicDepartment of Anesthesia and Intensive Care, Military Medical Academy Belgrade, Belgrade, Serbia.
Matej PodbregarDepartment for Internal Intensive Care, General Hospital Celje, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia.
Juan V LlauDepartment of Anesthesiology and Post-surgical Critical Care, University Hospital Doctor Peset, Valencia, Spain.
Manual Quintana-DiazIntensive Care Service, Hospital Universitario La Paz, Madrid, Spain.
Maria CronhjortDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-0444-8553
Carmen A PfortmuellerDepartment of Intensive Care, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Nihan YapiciDepartment of Anesthesiology and Reanimation, Dr Siyami Ersek Thoracic and Cardiovascular Surgery Center, University of Health Sciences, Istanbul, Turkey.
Nathan NielsenDivision of Pulmonary, Critical Care and Sleep Medicine, and Section of Transfusion Medicine and Therapeutic Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
Akshay ShahNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Harm-Jan de GroothDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Alexander P J VlaarDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Jimmy SchenkDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Senta Jorinde RaasveldDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
InPUT Study Group

Funding

National Health and Medical Research Council GNT1189490National Health and Medical Research Council GNT1194811
6 · The paper itself

Abstract

backgroundTransfusion practices among intensive care unit (ICU) patients with sepsis vary widely. While restrictive hemoglobin thresholds for red blood cell (RBC) transfusion are well studied, the indications and thresholds for platelet and plasma transfusions remain uncertain.

methodsWe performed a sepsis-specific sub-analysis of the International Point Prevalence Study of Intensive Care Unit Transfusion Practices, a prospective, multicenter, observational study capturing all adult ICU admissions during four pre-scheduled weeks between March 2019 and October 2022. Patients admitted with sepsis or septic shock, or who developed sepsis during their ICU stay, were included. We recorded demographics, daily laboratory values, and transfusion triggers. Primary endpoints were the proportions of patients receiving RBCs, platelets, or plasma; secondary endpoints were indications, pre-transfusion thresholds, and blood loss.

resultsAmong 3643 screened patients, 799 (22%) fulfilled sepsis criteria; within this subgroup, 317 (40%) received at least one blood component. RBCs were transfused in 269 patients (34%), primarily to address anemia or hemodynamic instability, at a mean pre-transfusion hemoglobin of 7.5 ± 1.4 g/dL, consistent with restrictive practice. Platelets were given to 78 patients (10%) for prophylaxis or active bleeding at a median count of 26 × 10

conclusionsThis largest international snapshot of septic ICU transfusion practices confirms adherence to restrictive RBC thresholds but reveals substantial variability in platelet and plasma use. These findings underscore the need for targeted trials to refine transfusion guidelines in sepsis.

Indexed as

Blood TransfusionErythrocyte TransfusionIntensive Care UnitsSepsisAgedFemaleHumansMaleMiddle AgedPlatelet TransfusionProspective Studies

Identifiers

PMID41122832
PMCPMC12704699

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.