Evidence map›Paper›PMID 41122809›Full record

ArticleBiochemistry2025

Active Site Residues Contribute to the Multistep Dynamics of Dicyclotyrosine Bound to CYP121A1 of

Patil Pranita Uttamrao, Layne J Jensen, D Fernando Estrada, Thenmalarchelvi Rathinavelan

Abstract read
In one paragraph

Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Patil Pranita UttamraoDepartment of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, Sangareddy Hyderabad, Telangana 502284, India.
Layne J JensenDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Science, University at Buffalo, Buffalo, New York 14203, United States.
D Fernando EstradaDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Science, University at Buffalo, Buffalo, New York 14203, United States.ORCID 0000-0002-7956-7610
Thenmalarchelvi RathinavelanDepartment of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, Sangareddy Hyderabad, Telangana 502284, India.ORCID 0000-0002-1142-0583

Funding

Noncompetitive inhibition of CYP121 dimers from Mycobacterium tuberculosisR21AI182823 · NIAID · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI ESTRADA, DAVID FERNANDO · 2024 to 2025
$443k
NIAID NIH HHS R21 AI182823
6 · The paper itself

Abstract

Cytochrome P450 121A1 (CYP121A1) of

Indexed as

Bacterial ProteinsCytochrome P-450 Enzyme SystemMycobacterium tuberculosisTyrosineCatalytic DomainMolecular Dynamics SimulationMutationProtein BindingBacterial Proteinscytochrome P-450 CYP121Cytochrome P-450 Enzyme SystemTyrosine

Identifiers

PMID41122809
PMCPMC12927084

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.