Evidence map›Paper›PMID 41122718›Full record

SynthesisFrontiers in endocrinology2025

Association between DDT or its byproducts and T2DM: a systematic review and meta-analysis.

Weijian Tian, Shaohui Bai, Ting Xie, Haolu Zha, Zhouning Yan, Shengze Zhang, Nan Wu, Jianhui Yuan, Huanle Luo, Qian Xie and 1 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Weijian TianShenzhen Nanshan Center for Disease Control and Prevention, Shenzhen, China.
Shaohui BaiShenzhen Nanshan Center for Disease Control and Prevention, Shenzhen, China.
Ting XieSchool of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Sun Yat-sen University, Shenzhen, China.
Haolu ZhaSchool of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Sun Yat-sen University, Shenzhen, China.
Zhouning YanShenzhen Nanshan Center for Disease Control and Prevention, Shenzhen, China.
Shengze ZhangSchool of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Sun Yat-sen University, Shenzhen, China.
Nan WuShenzhen Nanshan Center for Disease Control and Prevention, Shenzhen, China.
Jianhui YuanShenzhen Nanshan Center for Disease Control and Prevention, Shenzhen, China.
Huanle LuoSchool of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Sun Yat-sen University, Shenzhen, China.
Qian XieSchool of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Sun Yat-sen University, Shenzhen, China.
Ying JiangShenzhen Nanshan Center for Disease Control and Prevention, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Currently, type 2 diabetes mellitus (T2DM) is among the fastest-growing global health emergencies of the century. Emerging evidence from epidemiological studies suggests a potential positive association between exposure to dichlorodiphenyltrichloroethane (DDT) or its byproducts and an increasing risk of T2DM. Objective: We conducted a systematic review and meta-analysis to quantify the association between DDT or its byproducts and T2DM. Additionally, we aimed to identify the sources of heterogeneity contributing to the inconsistency of the results. Methods: Data analysis: assess the quality of the included studies using the Risk Of Bias In Non-randomized Studies of Exposure tool, determine the source of heterogeneity using subgroup analysis, sensitivity analysis and meta regression model based on a fixed-effects model, and analyze the publication bias using funnel plots, Egger's test, and Begg's test. Results: DDT and its byproducts were associated with the risk of developing T2DM (total OR: 1.13, 95% CI: 1.08-1.15, I Conclusions: The systematic review and meta-analysis offer quantifiable proof of a positive correlation between exposure to DDT or its byproducts and a higher risk of developing T2DM. Systematic Review Registration: https://inplasy.com, identifier INPLASY20258004.

Indexed as

DDTDiabetes Mellitus, Type 2Environmental ExposureHumansRisk FactorsDDTbyproductsDDTmeta-analysisquantitative evidenceT2DM

Identifiers

PMID41122718
PMCPMC12536502

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.