SynthesisFrontiers in endocrinology2025
The impact of maternal depression during pregnancy on the risk of gestational diabetes mellitus: a meta-analysis.
Synthesis in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- The impact of mental health disorders in pregnancy on obstetric and neonatal outcomes: A narrative review.Brain, behavior, & immunity - health · 2026Review
- Association between gestational diabetes, ethnicity and migrant length of residence: An Australian cohort study.Diabetic medicine : a journal of the British Diabetic Association · 2026Observational
- Obstetrical and Neonatal Outcomes in Pregnant Individuals With Anxiety Disorders.The journal of obstetrics and gynaecology research · 2026Article
- Intrauterine gestational diabetes mellitus, child anxiety, and internalizing symptoms: moderation by physical activity.Journal of the Endocrine Society · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Antenatal depression, defined as clinically significant depressive symptoms occurring during pregnancy, has been suggested to increase the risk of gestational diabetes mellitus (GDM), a glucose intolerance disorder with onset or first recognition during pregnancy. However, evidence regarding its relationship with GDM remains inconsistent. This meta-analysis aimed to quantitatively assess the association between antenatal depression and the risk of GDM. Methods: We systematically searched PubMed, Embase, Wanfang, and the Cochrane Library from inception to June 12, 2025, for observational studies reporting the association between depression during pregnancy and GDM. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model. Results: A total of eight studies were included in the meta-analysis. The pooled analysis showed that maternal depression during pregnancy was significantly associated with an increased risk of GDM (OR = 1.37, 95% CI: 1.20-1.54). Subgroup analyses based on country, depression assessment tool, and study design showed consistent results. Sensitivity analyses confirmed the stability of the results. No significant publication bias was detected. Conclusion: This meta-analysis suggests that maternal depression during pregnancy is associated with a significantly increased risk of developing GDM. Screening for depression in early pregnancy may represent a potential strategy to reduce the risk of GDM and improve maternal health outcomes.
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