Evidence map›Paper›PMID 41122687›Full record

ArticleFrontiers in cellular and infection microbiology2025

Alterations in peripheral blood NK cell subsets and function in patients with HBeAg-positive chronic hepatitis B during pregnancy.

Xiaokun Shen, Xiaosong Zhang, Yanqiu Cao, Li Zhang, Hongxia Yuan, Haixin Wang, Yarui Zhou, Shuo Diao, Xingshu Qi, Fujie Li and 2 more

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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaokun ShenDepartment of Immunology, School of Basic Medical Science, Jinzhou Medical University, Jinzhou, China.
Xiaosong ZhangDepartment of Immunology, School of Basic Medical Science, Jinzhou Medical University, Jinzhou, China.
Yanqiu CaoDepartment of Neonatology, Maternity and Children's Hospital, Jinzhou, China.
Li ZhangDepartment of Clinical Laboratory, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Hongxia YuanDepartment of Infectious Diseases, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Haixin WangDepartment of Immunology, School of Basic Medical Science, Jinzhou Medical University, Jinzhou, China.
Yarui ZhouDepartment of Immunology, School of Basic Medical Science, Jinzhou Medical University, Jinzhou, China.
Shuo DiaoCollaborative Innovation Center for Age-related Disease, Jinzhou Medical University, Jinzhou, China.
Xingshu QiCollaborative Innovation Center for Age-related Disease, Jinzhou Medical University, Jinzhou, China.
Fujie LiDepartment of Immunology, School of Basic Medical Science, Jinzhou Medical University, Jinzhou, China.
Qingjie FanDepartment of Immunology, School of Basic Medical Science, Jinzhou Medical University, Jinzhou, China.
Shinan LiDepartment of Immunology, School of Basic Medical Science, Jinzhou Medical University, Jinzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The majority of patients with chronic hepatitis B (CHB) are in the immune-tolerant phase during pregnancy, exhibiting relatively stable liver disease. However, some hepatitis B e antigen (HBeAg)-positive pregnant women may develop liver dysfunction, a condition with an unclear pathogenesis. Methods: In this study, we analyzed the phenotype and function of natural killer (NK) cell subsets using flow cytometry and enzyme-linked immunosorbent assay in HBeAg-positive pregnant women, HBeAg-negative pregnant women, and healthy pregnant controls. Results: We found that HBeAg-positive pregnant women exhibited a decreased proportion of peripheral blood CD56bright NK cells, which correlated negatively with HBV DNA loads and alanine transaminase (ALT) levels, whereas an increased proportion of CD56

Indexed as

Hepatitis B, ChronicHepatitis B e AntigensKiller Cells, NaturalLymphocyte SubsetsPregnancy Complications, InfectiousAdultAlanine TransaminaseCD56 AntigenDNA, ViralFemaleFlow CytometryHepatitis B virusHumansInterferon-gammaPregnancyViral LoadAlanine TransaminaseCD56 AntigenDNA, ViralHepatitis B e AntigensInterferon-gammachronic hepatitis BHBeAgIFN-γNKpregnancyTh17

Identifiers

PMID41122687
PMCPMC12535973

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.